Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

[pTyr1173]EGF受体多克隆抗体

ADI-905-753-100

100微克

多克隆

domestic rabbit

未共轭

磷酸化

人类, 大鼠

ADI-905-753-100

[pTyr1173]EGF受体多克隆抗体

兔

多克隆

磷酸化

抗体

100微克

人类, 大鼠

The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.

表皮生长因子受体, 表皮生长因子受体

Synthetic peptide corresponding to a portion of human EGF receptor phosphorylated at Tyr1173.

液体。 在PBS, pH值7.2, 含50% 甘油和0.09% 叠氮化钠

Detects a band of ~170kDa by Western blot.

免疫印迹

-20°C