Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

Sonic hedgehog monoclonal antibody (10H6)

ADI-905-860-100

100微升

单克隆

小鼠

未共轭

10H6

ADI-905-860-100

Sonic hedgehog monoclonal antibody (10H6)

小鼠

单克隆

抗体

100微升

10H6

IgG1

人类

Sonic Hedgehog (SHH) is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.

SHH

Recombinant human SHH (sonic hedgehog) (aa 24-197).

液体。 在PBS, pH值7.3, 含1% BSA, 50% 甘油和0.02% 叠氮化钠

Detects a band of ~50kDa (full length) by Western blot.

免疫印迹

-20°C