Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

Notch1单克隆抗体(3E12)

ADI-905-897-100

100微升

单克隆

小鼠

未共轭

3E12

ADI-905-897-100

Notch1单克隆抗体(3E12)

小鼠

单克隆

抗体

100微升

3E12

IgG2b

人类

Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

重组人类Notch1(氨基酸2300-2556)

液体。 在PBS, pH值7.3, 含1% BSA, 50% 甘油和0.02% 叠氮化钠

Detects a band of ~280kDa (full length) by Western blot.

免疫印迹

-20°C