产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶9单克隆抗体(5B4)
目录 :
ADI-AAM-139-E
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5B4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 5
| 参考文献 |
|---|
Yi S, Moore C, Lee R. Rapid cold-hardening protects Drosophila melanogaster from cold-induced apoptosis. Apoptosis. 2007;12:1183-93 pubmed
|
Jia L, Patwari Y, Kelsey S, Srinivasula S, Agrawal S, Alnemri E, et al. Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene. 2003;22:1589-99 pubmed
|
Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem. 2002;277:14127-34 pubmed
|
Liu J, Opipari A, Tan L, Jiang Y, Zhang Y, Tang H, et al. Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res. 2002;62:924-31 pubmed
|
Huang L, Mivechi N, Moskophidis D. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Mol Cell Biol. 2001;21:8575-91 pubmed
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产品信息
产品编号 :
ADI-AAM-139
目录代码 :
ADI-AAM-139-E
产品名称 :
胱氨酸-天冬氨酸蛋白酶9单克隆抗体(5B4)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
Pubmed号列表 :
17245639, 12642862, 11836241, 11830553, 11713291
克隆 :
5B4
抗体亚型 :
IgG1
物种活性 :
人类, 小鼠, 大鼠, 果蝇
背景 :
Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signalling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells, and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-9, also known as ICE-LAP61, Mch-62 or Apaf-33 is a 45 kDa protein that is involved in one of the relatively well characterized caspase cascades. It is triggered by Cytochrome C release from the mitochondria, which promotes the activation of caspase-9 by forming a complex with Apaf-1 in the presence of dATP. Once activated, caspase-9 initiates a caspase cascade involving caspase-3, -6, and -7. The active form of caspase-9 is composed of a 32-35 kDa subunit and 10 kDa subunit. Caspase-9 is expressed in a variety of tissues.
免疫原 :
Recombinant human caspase-9 (N-terminal fragment).
缓冲液 :
液体。 在PBS, pH值7.2, 含50% 甘油
用途 :
Detects a band of ~46-50kDa by Western blot.
应用摘要 :
免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。