产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
ELISA/assay
产品名称 :
HO-1(人类), 酶联免疫吸附试剂盒
目录 :
ADI-EKS-800
规格 :
96 wells
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 11
参考文献
Javkhedkar A, Banday A. Antioxidant resveratrol restores renal sodium transport regulation in SHR. Physiol Rep. 2015;3: pubmed 出版商
Calò L, Savoia C, Davis P, Pagnin E, Ravarotto V, Maiolino G. Relationship between NOX4 level and angiotensin II signaling in Gitelman's syndrome. Implications with hypertension. Int J Clin Exp Med. 2015;8:7487-96 pubmed
Padmini E, Tharani J. Differential expression of HO-1 and CYP1A2 during up-regulation of ERK in stressed fish hepatocytes. Environ Monit Assess. 2015;187:4147 pubmed 出版商
Banday A, Lokhandwala M. Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress. Hypertension. 2013;62:512-7 pubmed 出版商
Song W, Zukor H, Lin S, Liberman A, Tavitian A, Mui J, et al. Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. J Neurochem. 2012;123:325-36 pubmed 出版商
Song W, Zukor H, Lin S, Hascalovici J, Liberman A, Tavitian A, et al. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. J Neurosci. 2012;32:10841-53 pubmed
Bao W, Rong S, Zhang M, Yu X, Zhao Y, Xiao X, et al. Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population. PLoS ONE. 2012;7:e32223 pubmed 出版商
Bharucha A, Kulkarni A, Choi K, Camilleri M, Lempke M, Brunn G, et al. First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans. Clin Pharmacol Ther. 2010;87:187-90 pubmed 出版商
Kirino Y, Takeno M, Iwasaki M, Ueda A, Ohno S, Shirai A, et al. Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther. 2005;7:R616-24 pubmed
Kravets A, Hu Z, Miralem T, Torno M, Maines M. Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. J Biol Chem. 2004;279:19916-23 pubmed
Philippidis P, Mason J, Evans B, Nadra I, Taylor K, Haskard D, et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004;94:119-26 pubmed
产品信息
产品编号 :
ADI-EKS-800
目录代码 :
ADI-EKS-800
产品名称 :
HO-1(人类), 酶联免疫吸附试剂盒
产品类型 :
Kit
规格 :
96 wells
Pubmed号列表 :
26221292, 22881289, 22875919, 22427825, 19956091, 15899048, 14988408, 14656926
产品描述 :
The HO-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 2.5 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.
物种活性 :
人类
背景 :
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
别名 :
血红素氧化酶
用途 :
For the quantitative determination of human heme oxygenase-1 in cell lysates and tissue extracts. Cited sample types include serum and plasma.
应用摘要 :
ELISA, Colorimetric detection
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。