产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
ELISA/assay
产品名称 :
HO-1(大鼠), 酶联免疫吸附试剂盒
目录 :
ADI-EKS-810A
规格 :
96 wells
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 11
参考文献
Tomonaga T, Izumi H, Yoshiura Y, Myojo T, Oyabu T, Lee B, et al. Assessment of Pulmonary Toxicity Induced by Inhaled Toner with External Additives. Biomed Res Int. 2017;2017:4245309 pubmed 出版商
Kowalczyk A, JeleÅ„ A, Å»ebrowska M, Balcerczak E, GorÄ…ca A. BQ123 Stimulates Skeletal Muscle Antioxidant Defense via Nrf2 Activation in LPS-Treated Rats. Oxid Med Cell Longev. 2016;2016:2356853 pubmed 出版商
Chuang J, Huang J, Tsai S, Sun H, Yang S, Chuang P, et al. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med. 2015;89:274-86 pubmed 出版商
Ehrnthaller C, Flierl M, Perl M, Denk S, Unnewehr H, Ward P, et al. The molecular fingerprint of lung inflammation after blunt chest trauma. Eur J Med Res. 2015;20:70 pubmed 出版商
Han F, Guo Y, Xu L, Hou N, Han F, Sun X. Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway. Cell Physiol Biochem. 2015;36:1480-90 pubmed
Connolly M, Fernández Cruz M, Navas J. Recovery of redox homeostasis altered by CuNPs in H4IIE liver cells does not reduce the cytotoxic effects of these NPs: an investigation using aryl hydrocarbon receptor (AhR) dependent antioxidant activity. Chem Biol Interact. 2015;228:57-68 pubmed 出版商
Morimoto Y, Oyabu T, Horie M, Kambara T, Izumi H, Kuroda E, et al. Pulmonary toxicity of printer toner following inhalation and intratracheal instillation. Inhal Toxicol. 2013;25:679-90 pubmed 出版商
Jain K, Suryakumar G, Prasad R, Ganju L. Upregulation of cytoprotective defense mechanisms and hypoxia-responsive proteins imparts tolerance to acute hypobaric hypoxia. High Alt Med Biol. 2013;14:65-77 pubmed 出版商
Saeki I, Matsuura T, Hayashida M, Taguchi T. Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine. Pediatr Surg Int. 2011;27:857-62 pubmed 出版商
Furukawa Y, Urano T, Minamimura M, Nakajima M, Okuyama S, Furukawa S. 4-Methylcatechol-induced heme oxygenase-1 exerts a protective effect against oxidative stress in cultured neural stem/progenitor cells via PI3 kinase/Akt pathway. Biomed Res. 2010;31:45-52 pubmed
Wang J, Ma H, Boor P, Ramanujam V, Ansari G, Khan M. Up-regulation of heme oxygenase-1 in rat spleen after aniline exposure. Free Radic Biol Med. 2010;48:513-8 pubmed 出版商
产品信息
产品编号 :
ADI-EKS-810A
目录代码 :
ADI-EKS-810A
产品名称 :
HO-1(大鼠), 酶联免疫吸附试剂盒
产品类型 :
Kit
规格 :
96 wells
Pubmed号列表 :
26424114, 26160485, 25617484, 24102468, 23537263, 21113784, 20203419, 19969074
产品描述 :
The HO-1 (rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 3 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.
物种活性 :
大鼠
背景 :
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
别名 :
血红素氧化酶
用途 :
For the quantitative determination of rat HO-1 in cell lysates, plasma, serum, and tissue. Cited sample type includes bronchoalveolar lavage fluid.
应用摘要 :
ELISA, Colorimetric detection
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。