Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

DNA-topoisomerase II α monoclonal antibody (1C5)

ADI-KAM-CC210-E

100微克

单克隆

小鼠

未共轭

1C5

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪

ADI-KAM-CC210-E

DNA-topoisomerase II α monoclonal antibody (1C5)

小鼠

单克隆

抗体

100微克

1C5

IgG2a

人类

DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

Recombinant human DNA-topoisomerase IIα (C-terminal fragment).

液体。 在PBS, pH值7.2, 含50% 甘油

Detects a band of 170kDa by Western blot.

FC, 免疫细胞化学, 免疫组化, 免疫沉淀, 免疫印迹

-20°C