Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

nNOS多克隆抗体

ADI-KAP-NO030-D

50微克

多克隆

domestic rabbit

未共轭

小鼠, 大鼠

免疫印迹, 免疫组化

ADI-KAP-NO030-D

nNOS多克隆抗体

兔

多克隆

抗体

50微克

小鼠, 大鼠

The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Nitric oxide synthase (neuronal), NOS I

Synthetic peptide corresponding to the sequence near the C-terminus of human nNOS.

液体。 在PBS, pH值7.2, 含50% 甘油和0.09% 叠氮化钠

Detects a band of ~155kDa by Western blot.

免疫组化(PS), 免疫印迹

-20°C