产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
Akt polyclonal antibody
目录 :
ADI-KAP-PK004-D
规格 :
50微克
价格 :
155美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀
更多信息或购买 :
文章摘录数: 5
参考文献
Prysyazhna O, Burgoyne J, Scotcher J, Grover S, Kass D, Eaton P. Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G I? Oxidation. J Biol Chem. 2016;291:17427-36 pubmed 出版商
Agyeman A, Jun W, Proia D, Kim C, Skor M, Kocherginsky M, et al. Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer. Horm Cancer. 2016;7:114-26 pubmed 出版商
Monsivais D, Dyson M, Yin P, Navarro A, Coon J, Pavone M, et al. Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation. Fertil Steril. 2016;105:1266-1273 pubmed 出版商
Mátyás C, Németh B, Oláh A, Hidi L, Birtalan E, Kellermayer D, et al. The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus. Cardiovasc Diabetol. 2015;14:145 pubmed 出版商
Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochem Pharmacol. 2015;98:119-31 pubmed 出版商
产品信息
产品编号 :
ADI-KAP-PK004
目录代码 :
ADI-KAP-PK004-D
产品名称 :
Akt polyclonal antibody
宿主物种 :
克隆性 :
多克隆
产品类型 :
抗体
规格 :
50微克
标价(美元) :
155美元
Pubmed号列表 :
11518769, 10212287
物种活性 :
人类, 小鼠, 大鼠
背景 :
The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.
别名 :
PKB, 蛋白激酶B, RAC
免疫原 :
Synthetic peptide corresponding to a portion of human Akt. The sequence is completely conserved in rat and bovine.
缓冲液 :
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
用途 :
Detects a band of ~59kDa by Western blot.
应用摘要 :
免疫组化(PS), 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。