产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HO-1单克隆抗体(HO-1-1)
目录 :
ADI-OSA-110-J
规格 :
1毫克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HO-1-1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 20
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:2000; 图 7a
  • 免疫印迹; 小鼠; 1:2000; 图 2b
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
Starheim K, Holien T, Misund K, Johansson I, Baranowska K, Sponaas A, et al. Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells. Blood Cancer J. 2016;6:e446 pubmed 出版商
Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y. Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol Appl Pharmacol. 2016;305:161-168 pubmed 出版商
Wang L, Yokoyama K, Lin C, Chen T, Hsiao H, Chiang P, et al. Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice. Sci Rep. 2016;6:26358 pubmed 出版商
Wichmann H, Vocke F, Brinkhoff T, Simon M, Richter Landsberg C. Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin. Mar Drugs. 2015;13:7113-23 pubmed 出版商
Pettersen K, Monsen V, HakvÃ¥g Pettersen C, Overland H, Pettersen G, Samdal H, et al. DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy. Free Radic Biol Med. 2016;90:158-72 pubmed 出版商
Harada S, Nakagawa T, Yokoe S, Edogawa S, Takeuchi T, Inoue T, et al. Autophagy Deficiency Diminishes Indomethacin-Induced Intestinal Epithelial Cell Damage through Activation of the ERK/Nrf2/HO-1 Pathway. J Pharmacol Exp Ther. 2015;355:353-61 pubmed 出版商
Ishima Y, Narisoko T, Kragh Hansen U, Kotani S, Nakajima M, Otagiri M, et al. Nitration of indoxyl sulfate facilitates its cytotoxicity in human renal proximal tubular cells via expression of heme oxygenase-1. Biochem Biophys Res Commun. 2015;465:481-7 pubmed 出版商
Chen H, Lu P, Chen B, Hsiao M, Ho W, Tseng C. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015;1852:2195-201 pubmed 出版商
Nguyen Ho Bouldoires T, Clapéron A, Mergey M, Wendum D, Desbois Mouthon C, Tahraoui S, et al. Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells. Free Radic Biol Med. 2015;89:34-46 pubmed 出版商
Lee S, Yi C, Heo R, Song D, Cho Y, Jeong Y, et al. Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice. PLoS ONE. 2015;10:e0131671 pubmed 出版商
Choi S, Paek H, Yu J. Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells. Int J Nanomedicine. 2015;10:3217-29 pubmed 出版商
Jabs A, Oelze M, Mikhed Y, Stamm P, Kröller Schön S, Welschof P, et al. Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats. Vascul Pharmacol. 2015;71:181-91 pubmed 出版商
Crowston J, Kong Y, Trounce I, Dang T, Fahy E, Bui B, et al. An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse. Exp Eye Res. 2015;141:3-8 pubmed 出版商
Lawal A, Zhang M, Dittmar M, Lulla A, Araujo J. Heme oxygenase-1 protects endothelial cells from the toxicity of air pollutant chemicals. Toxicol Appl Pharmacol. 2015;284:281-291 pubmed 出版商
Vogler M, Zieseniss A, Hesse A, Levent E, Tiburcy M, Heinze E, et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015;467:2141-9 pubmed 出版商
Kang H, Yi Y, Hong Y, Kim H, Jang Y, Seong Y, et al. HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction. Sci Rep. 2014;4:7201 pubmed 出版商
Gemici B, Tan R, Birsen I, Ä°zgüt Uysal V. Gastroprotective effect of orexin-A and heme oxygenase system. J Surg Res. 2015;193:626-33 pubmed 出版商
Li L, Yang N, Nin L, Zhao Z, Chen L, Yu J, et al. Chinese herbal medicine formula tao hong si wu decoction protects against cerebral ischemia-reperfusion injury via PI3K/Akt and the Nrf2 signaling pathway. J Nat Med. 2015;69:76-85 pubmed 出版商
Gleixner A, Pulugulla S, Pant D, Posimo J, Crum T, Leak R. Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat. Cell Tissue Res. 2014;357:43-54 pubmed 出版商
产品信息
产品编号 :
ADI-OSA-110
目录代码 :
ADI-OSA-110-J
产品名称 :
HO-1单克隆抗体(HO-1-1)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
1毫克
Pubmed号列表 :
26633426, 26585906, 26404472, 26277392, 26232688, 25869522, 25620054, 25467193, 25263508, 24723229
克隆 :
HO-1-1
抗体亚型 :
IgG1
物种活性 :
人类, 小鼠, 大鼠, 狗, 牛
背景 :
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
别名 :
HMOX1, Hsp32, 热休克蛋白32, 血红素氧化酶
免疫原 :
Synthetic peptide corresponding to the sequence near the N-terminus of human HO-1.
缓冲液 :
液体。 在PBS含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~32kDa by Western blot.
应用摘要 :
FC, 免疫细胞化学, 免疫组化(PS), 免疫印迹
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。