产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP70/HSP72单克隆抗体(C92F3A-5)(AP共轭标签)
目录 :
ADI-SPA-810AP-F
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AP
克隆名称 :
C92F3A-5
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 53
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 人类; 1:50; 图 7
  • 免疫印迹; 人类; 1:10,000; 图 3
  • 免疫印迹; 小鼠; 1:10,000; 图 1
Lin P, Folorunso O, Taglialatela G, Pierce A. Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells. J Neurosci Res. 2016;94:671-82 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Larabee C, Georgescu C, Wren J, Plafker S. Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons. BMC Neurosci. 2015;16:76 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1
Zhou J, Wan J, Gao X, Zhang X, Jaffrey S, Qian S. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature. 2015;526:591-4 pubmed 出版商
Takagi R, Ogasawara R, Tsutaki A, Nakazato K, Ishii N. Regional adaptation of collagen in skeletal muscle to repeated bouts of strenuous eccentric exercise. Pflugers Arch. 2016;468:1565-72 pubmed 出版商
Xie F, Zhan R, Yan L, Gong J, Zhao Y, Ma J, et al. Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats. Cell Stress Chaperones. 2016;21:907-14 pubmed 出版商
Sclip A, Bacaj T, Giam L, Sudhof T. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS ONE. 2016;11:e0158295 pubmed 出版商
Podgorski K, Ranganathan G. Brain heating induced by near-infrared lasers during multiphoton microscopy. J Neurophysiol. 2016;116:1012-23 pubmed 出版商
Chooi W, Chan B. Compression loading-induced stress responses in intervertebral disc cells encapsulated in 3D collagen constructs. Sci Rep. 2016;6:26449 pubmed 出版商
Veit G, Oliver K, Apaja P, Perdomo D, Bidaud Meynard A, Lin S, et al. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol. 2016;14:e1002462 pubmed 出版商
Kasza A, Hunya A, Frank Z, Fulop F, Torok Z, Balogh G, et al. Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;53:557-71 pubmed 出版商
Lavinsky D, Wang J, Huie P, Dalal R, Lee S, Lee D, et al. Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula. Invest Ophthalmol Vis Sci. 2016;57:2488-500 pubmed 出版商
Gutierrez E, Seebacher N, Arzuman L, Kovacevic Z, Lane D, Richardson V, et al. Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochim Biophys Acta. 2016;1863:1665-81 pubmed 出版商
Andreeva N, Zatsepina O, Garbuz D, Evgen ev M, Belyavsky A. Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells. Cell Stress Chaperones. 2016;21:727-33 pubmed 出版商
Kim J, Son Y, Jung M, Jeong Y, Kim S, Lee S, et al. Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling. Mol Med Rep. 2016;13:4666-70 pubmed 出版商
Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2017;72:299-308 pubmed 出版商
Peppler W, Anderson Z, Sutton C, Rector R, Wright D. Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice. Am J Physiol Regul Integr Comp Physiol. 2016;310:R934-42 pubmed 出版商
Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, et al. Yeast Two-Hybrid and One-Hybrid Screenings Identify Regulators of hsp70 Gene Expression. J Cell Biochem. 2016;117:2109-17 pubmed 出版商
Frara N, Abdelmagid S, Tytell M, Amin M, Popoff S, Safadi F, et al. Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping. BMC Musculoskelet Disord. 2016;17:34 pubmed 出版商
Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, et al. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016;6:19174 pubmed 出版商
Shi L, Gehin T, Chevolot Y, Souteyrand E, Mangé A, Solassol J, et al. Anti-heat shock protein autoantibody profiling in breast cancer using customized protein microarray. Anal Bioanal Chem. 2016;408:1497-506 pubmed 出版商
Negishi T, Matsumoto M, Kojima M, Asai R, Kanehira T, Sakaguchi F, et al. Diphenylarsinic Acid Induced Activation of Cultured Rat Cerebellar Astrocytes: Phosphorylation of Mitogen-Activated Protein Kinases, Upregulation of Transcription Factors, and Release of Brain-Active Cytokines. Toxicol Sci. 2016;150:74-83 pubmed 出版商
Sarkar S, Leo B, Carranza C, Chen S, Rivas Santiago C, Porter A, et al. Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. PLoS ONE. 2015;10:e0143077 pubmed 出版商
Clemente Vicario F, Alvarez C, ROWELL J, Roy S, London C, Kisseberth W, et al. Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLoS ONE. 2015;10:e0142007 pubmed 出版商
Briassouli E, Tzanoudaki M, Goukos D, Routsi C, Nanas S, Vardas K, et al. Glutamine may repress the weak LPS and enhance the strong heat shock induction of monocyte and lymphocyte HSP72 proteins but may not modulate the HSP72 mRNA in patients with sepsis or trauma. Biomed Res Int. 2015;2015:806042 pubmed 出版商
Kern P, Cramp R, Seebacher F, Ghanizadeh Kazerouni E, Franklin C. Plasticity of protective mechanisms only partially explains interactive effects of temperature and UVR on upper thermal limits. Comp Biochem Physiol A Mol Integr Physiol. 2015;190:75-82 pubmed 出版商
Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed 出版商
Jiang Q, Zhang Z, Li S, Wang Z, Ma Y, Hu Y. Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells. Mol Med Rep. 2015;12:6517-26 pubmed 出版商
Smith B, Simpson D, Miller R, Erdman J, O Brien W. Contrast Ultrasound Imaging Does Not Affect Heat Shock Protein 70 Expression in Cholesterol-Fed Rabbit Aorta. J Ultrasound Med. 2015;34:1209-16 pubmed 出版商
Jeong Y, Jung M, Son Y, Jang J, Lee Y, Kim S, et al. Coniferyl aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function. PLoS ONE. 2015;10:e0128552 pubmed 出版商
Alexandrova E, Yallowitz A, Li D, Xu S, Schulz R, Proia D, et al. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature. 2015;523:352-6 pubmed 出版商
Kim J, Lee Y, Choi D, Yi H. Expression of Heat Shock Proteins (HSPs) in Aged Skeletal Muscles Depends on the Frequency and Duration of Exercise Training. J Sports Sci Med. 2015;14:347-53 pubmed
Tamura Y, Kitaoka Y, Matsunaga Y, Hoshino D, Hatta H. Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle. J Physiol. 2015;593:2707-20 pubmed 出版商
Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, et al. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015;45:2028-41 pubmed 出版商
Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015;64:599-608 pubmed 出版商
Schilling D, Kühnel A, Konrad S, Tetzlaff F, Bayer C, Yaglom J, et al. Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Lett. 2015;360:294-301 pubmed 出版商
Morlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed 出版商
Liu Y, Yu Y, Chu H, Bing D, Wang S, Zhou L, et al. 17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro. Neurosci Lett. 2015;588:72-7 pubmed 出版商
Kabbaj F, Lu S, Faouzi M, Meddah B, Proksch P, Cherrah Y, et al. Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity. Bioorg Med Chem. 2015;23:126-31 pubmed 出版商
Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed 出版商
Ramirez V, Krueger W, Aneskievich B. TNIP1 reduction of HSPA6 gene expression occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors. Gene. 2015;555:430-7 pubmed 出版商
Leyk J, Goldbaum O, Noack M, Richter Landsberg C. Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol Neurosci. 2015;55:1031-46 pubmed 出版商
Roufayel R, Johnston D, Mosser D. The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70. Cell Death Dis. 2014;5:e1546 pubmed 出版商
Dang V, Tanabe K, Tanaka Y, Tokumoto N, Misumi T, Saeki Y, et al. Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. PLoS ONE. 2014;9:e110748 pubmed 出版商
Ramirez V, Stamatis M, Shmukler A, Aneskievich B. Basal and stress-inducible expression of HSPA6 in human keratinocytes is regulated by negative and positive promoter regions. Cell Stress Chaperones. 2015;20:95-107 pubmed 出版商
Agulla J, Brea D, Campos F, Sobrino T, Argibay B, Al Soufi W, et al. In vivo theranostics at the peri-infarct region in cerebral ischemia. Theranostics. 2013;4:90-105 pubmed 出版商
Teixeira A, Cox R, Egmond M. Furan fatty acids efficiently rescue brain cells from cell death induced by oxidative stress. Food Funct. 2013;4:1209-15 pubmed 出版商
Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed 出版商
Mitra S, Giesselman B, De Jesús Andino F, Foster T. Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70. Lasers Surg Med. 2011;43:632-43 pubmed 出版商
Needham P, Mikoluk K, Dhakarwal P, Khadem S, Snyder A, Subramanya A, et al. The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation. J Biol Chem. 2011;286:43611-21 pubmed 出版商
Jin G, Hong T, Inoue S, Urano T, Cho S, Otsu K, et al. Augmentation of immune cell activity against tumor cells by Rauwolfia radix. J Ethnopharmacol. 2002;81:365-72 pubmed
Roigas J, Wallen E, Loening S, Moseley P. Estramustine phosphate enhances the effects of hyperthermia and induces the small heat shock protein HSP27 in the human prostate carcinoma cell line PC-3. Urol Res. 2002;30:130-5 pubmed
Demirel H, Powers S, Zergeroglu M, Shanely R, Hamilton K, Coombes J, et al. Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol (1985). 2001;91:2205-12 pubmed
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产品信息
产品编号 :
ADI-SPA-810AP
目录代码 :
ADI-SPA-810AP-F
产品名称 :
HSP70/HSP72单克隆抗体(C92F3A-5)(AP共轭标签)
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
碱性磷酸酶
产品类型 :
抗体
规格 :
200微克
Pubmed号列表 :
23719714, 12127238, 12086019, 11641363, 8175569
克隆 :
C92F3A-5
抗体亚型 :
IgG1
物种活性 :
Human, Mouse, Rat, Teal, Fish, Dog, Chicken, Bovine
背景 :
The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
别名 :
Hsp70, HspA1A, 热休克蛋白70, HspA1B, Hsp72
免疫原 :
天然人类Hsp70
缓冲液 :
液体。 在PBS含50% 甘油和0.09% 叠氮化钠
应用摘要 :
酶联免疫吸附测定, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。