产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSC70/HSP73单克隆抗体(1B5)
目录 :
ADI-SPA-815-D
规格 :
50微克
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
1B5
反应物种 :
Garra rufa, 人类, 小鼠, 大鼠, 犬, 鸡, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 32
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 1d
Mailer R, Gisterå A, Polyzos K, Ketelhuth D, Hansson G. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:15655 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Dhamad A, Zhou Z, Zhou J, Du Y. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction. PLoS ONE. 2016;11:e0160312 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 1
Stewart M, Plante I, Penuela S, Laird D. Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. PLoS ONE. 2016;11:e0154162 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300; 图 2
Trieb K, Sulzbacher I, Kubista B. Recurrence rate and progression of chondrosarcoma is correlated with heat shock protein expression. Oncol Lett. 2016;11:521-524 pubmed
  • 免疫印迹; 人类; 图 s3
Kowal J, Arras G, Colombo M, Jouve M, Morath J, Primdal Bengtson B, et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc Natl Acad Sci U S A. 2016;113:E968-77 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff Yoessle S, Diem M, et al. RAL-1 controls multivesicular body biogenesis and exosome secretion. J Cell Biol. 2015;211:27-37 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 4
Ferreira J, Soares A, Ramalho J, Pereira P, Girao H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep. 2015;5:10210 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sultmann H, et al. Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 2015;11:e1004712 pubmed 出版商
  • 免疫印迹; Garra rufa
Oksala N, Ekmekçi F, Ozsoy E, Kirankaya S, Kokkola T, Emecen G, et al. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress. Redox Biol. 2014;3:25-8 pubmed 出版商
  • 免疫印迹; 人类
Suico M, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, et al. The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism. J Biol Chem. 2014;289:26143-54 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Mori F, Watanabe Y, Miki Y, Tanji K, Odagiri S, Eto K, et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases. Neuropathology. 2014;34:140-7 pubmed
  • 免疫细胞化学; 人类
Kitamura A, Inada N, Kubota H, Matsumoto G, Kinjo M, Morimoto R, et al. Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes Cells. 2014;19:209-24 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2500; 图 4
Reina C, Nabet B, Young P, Pittman R. Basal and stress-induced Hsp70 are modulated by ataxin-3. Cell Stress Chaperones. 2012;17:729-42 pubmed 出版商
Kopp Y, Lang W, Schuster T, Martínez Limón A, Hofbauer H, Ernst R, et al. CHIP as a membrane-shuttling proteostasis sensor. elife. 2017;6: pubmed 出版商
Seo J, Park J, Lee E, Vo T, Choi H, Kim J, et al. ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation. Nat Commun. 2016;7:12882 pubmed 出版商
Santio N, Landor S, Vahtera L, Ylä Pelto J, Paloniemi E, Imanishi S, et al. Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget. 2016;7:43220-43238 pubmed 出版商
Veit G, Oliver K, Apaja P, Perdomo D, Bidaud Meynard A, Lin S, et al. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol. 2016;14:e1002462 pubmed 出版商
Andreeva N, Zatsepina O, Garbuz D, Evgen ev M, Belyavsky A. Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells. Cell Stress Chaperones. 2016;21:727-33 pubmed 出版商
Gleixner A, Posimo J, Pant D, Henderson M, Leak R. Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury. Mol Neurobiol. 2016;53:4939-60 pubmed 出版商
Schmitz Rohmer D, Probst S, Yang Z, Laurent F, Stadler M, Zuniga A, et al. NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development. PLoS ONE. 2015;10:e0136566 pubmed 出版商
Helenius T, Misiorek J, Nyström J, Fortelius L, Habtezion A, Liao J, et al. Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. Mol Biol Cell. 2015;26:2298-310 pubmed 出版商
Heimdal K, Sanchez Guixé M, Aukrust I, Bollerslev J, Bruland O, Jablonski G, et al. STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity. Orphanet J Rare Dis. 2014;9:146 pubmed 出版商
Gleixner A, Pulugulla S, Pant D, Posimo J, Crum T, Leak R. Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat. Cell Tissue Res. 2014;357:43-54 pubmed 出版商
Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico M, et al. Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter. Sci Rep. 2014;4:4258 pubmed 出版商
Honegger A, Leitz J, Bulkescher J, Hoppe Seyler K, Hoppe Seyler F. Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells. Int J Cancer. 2013;133:1631-42 pubmed 出版商
Bento C, Marques F, Fernandes R, Pereira P. Methylglyoxal alters the function and stability of critical components of the protein quality control. PLoS ONE. 2010;5:e13007 pubmed 出版商
Moerdyk Schauwecker M, Hwang S, Grdzelishvili V. Analysis of virion associated host proteins in vesicular stomatitis virus using a proteomics approach. Virol J. 2009;6:166 pubmed 出版商
Li P, Itoh N, Watanabe M, Shi Y, Liu P, Yang H, et al. Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens. J Virol. 2009;83:37-46 pubmed 出版商
Lu H, Sun T, Matsuzaki T, Yi X, Eswara J, Bouley R, et al. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007;282:28721-32 pubmed
Tetzlaff J, Tanzer L, Jones K. Exogenous androgen treatment delays the stress response following hamster facial nerve injury. J Neuroendocrinol. 2007;19:383-9 pubmed
Meinander A, Söderström T, Kaunisto A, Poukkula M, Sistonen L, Eriksson J. Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort. J Immunol. 2007;178:3944-53 pubmed
Yamano T, Murata S, Shimbara N, Tanaka N, Chiba T, Tanaka K, et al. Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing. J Exp Med. 2002;196:185-96 pubmed
产品信息
产品编号 :
ADI-SPA-815
目录代码 :
ADI-SPA-815-D
产品名称 :
HSC70/HSP73单克隆抗体(1B5)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
26305214, 25958982, 25904331, 25760330, 25258038, 24723229, 23526637, 22777893, 20885985, 18945763
克隆 :
1B5
抗体亚型 :
IgG2a
物种活性 :
Human, Mouse, Rat, Turtle, Sheep, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Dog, Chicken, Bovine
背景 :
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
别名 :
热休克蛋白70, Hsc70, Hsp73
免疫原 :
天然仓鼠Hsc70(Hsp73)
缓冲液 :
液体。 在PBS, pH值7.2, 含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~73kDa by Western blot.
应用摘要 :
酶联免疫吸附测定, FC, 免疫细胞化学, IF, 免疫组化(PS), 免疫沉淀, 免疫印迹, 电子显微镜
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。