产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP90单克隆抗体(AC88)
目录 :
ADI-SPA-830-J
规格 :
1毫克
价格 :
1587美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
AC88
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 36
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:4000; 图 9a
Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4d
Adachi E, Sakai K, Nishiuchi T, Imamura R, Sato H, Matsumoto K. Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma. Oncotarget. 2016;7:70779-70793 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Hogg S, Newbold A, Vervoort S, Cluse L, Martin B, Gregory G, et al. BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members. Mol Cancer Ther. 2016;15:2030-41 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Kruger L, O Malley H, Hull J, Kleeman A, Patino G, Isom L. ?1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. J Neurosci. 2016;36:6213-24 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Tribollet V, Barenton B, Kroiss A, Vincent S, Zhang L, Forcet C, et al. miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERR?. PLoS ONE. 2016;11:e0156445 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
Huang K, Chen Z, Jiang Y, Akare S, Kolber Simonds D, Condon K, et al. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016;15:1208-16 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Lee J, Kuo C, Tsai S, Cheng S, Chen S, Chan H, et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Front Pharmacol. 2016;7:81 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
MikyÅ¡ková R, Å tÄ›pánek I, Indrová M, Bieblová J, Šímová J, Truxová I, et al. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol. 2016;48:953-64 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 表 1
  • 免疫印迹; 人类; 1:500; 表 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed 出版商
  • 流式细胞仪; 人类
Dudek Perić A, Ferreira G, Muchowicz A, Wouters J, Prada N, Martin S, et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res. 2015;75:1603-14 pubmed 出版商
  • 免疫印迹; 小鼠
Gong J, Weng D, Eguchi T, Murshid A, Sherman M, Song B, et al. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015;34:5460-71 pubmed 出版商
  • 流式细胞仪; 人类; 1:100
Martin S, Dudek Perić A, Maes H, Garg A, Gabrysiak M, Demirsoy S, et al. Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells. Biochem Pharmacol. 2015;93:290-304 pubmed 出版商
  • 免疫印迹; 小鼠
Moutaoufik M, El Fatimy R, Nassour H, Gareau C, Lang J, Tanguay R, et al. UVC-induced stress granules in mammalian cells. PLoS ONE. 2014;9:e112742 pubmed 出版商
  • 免疫印迹; 鸡
Blanc S, Ruggiero F, Birot A, Acloque H, Decimo D, Lerat E, et al. Subcellular localization of ENS-1/ERNI in chick embryonic stem cells. PLoS ONE. 2014;9:e92039 pubmed 出版商
  • 免疫沉淀; 人类; 图 6
  • 免疫印迹; 人类; 图 6
Bots M, Verbrugge I, Martin B, Salmon J, Ghisi M, Baker A, et al. Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 2014;123:1341-52 pubmed 出版商
  • 免疫印迹; 人类
Mao R, Rubio V, Chen H, Bai L, Mansour O, Shi Z. OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death Dis. 2013;4:e491 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, et al. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes. Cell Stress Chaperones. 2012;17:757-63 pubmed 出版商
  • 免疫印迹; 大鼠
Peng H, Morishima Y, Pratt W, Osawa Y. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. J Biol Chem. 2012;287:1556-65 pubmed 出版商
Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval J, et al. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018;9:1431 pubmed 出版商
Fedoseienko A, Wieringa H, Wisman G, Duiker E, Reyners A, Hofker M, et al. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PLoS ONE. 2016;11:e0165385 pubmed 出版商
Kasza A, Hunya A, Frank Z, Fulop F, Torok Z, Balogh G, et al. Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;53:557-71 pubmed 出版商
Kallifatidis G, Munoz D, Singh R, Salazar N, Hoy J, Lokeshwar B. β-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation. Mol Cancer Res. 2016;14:493-503 pubmed 出版商
Carter E, Gupta N, Ragsdale S. High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor. J Biol Chem. 2016;291:2196-222 pubmed 出版商
Baker A, Gregory G, Verbrugge I, Kats L, Hilton J, Vidacs E, et al. The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia. Cancer Res. 2016;76:1158-69 pubmed 出版商
Watkins R, Evans Molina C, Terrell J, Day K, Guindon L, Restrepo I, et al. Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes. Transl Res. 2016;168:96-106.e1 pubmed 出版商
Park Y, Lee K, Park S, Kim J, Kang E, Kim S, et al. Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer. J Breast Cancer. 2015;18:249-55 pubmed 出版商
Matthews G, Mehdipour P, Cluse L, Falkenberg K, Wang E, Roth M, et al. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. 2015;126:2392-403 pubmed 出版商
Saeed H, Shalaby M, Embaby A, Ismael M, Pathan A, Ataya F, et al. The Arabian camel Camelus dromedarius heat shock protein 90α: cDNA cloning, characterization and expression. Int J Biol Macromol. 2015;81:195-204 pubmed 出版商
Di Giancamillo A, Rossi R, Pastorelli G, Deponti D, Carollo V, Casamassima D, et al. The effects of dietary verbascoside on blood and liver oxidative stress status induced by a high n-6 polyunsaturated fatty acids diet in piglets. J Anim Sci. 2015;93:2849-59 pubmed 出版商
Sailland J, Tribollet V, Forcet C, Billon C, Barenton B, Carnesecchi J, et al. Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration. Proc Natl Acad Sci U S A. 2014;111:15108-13 pubmed 出版商
Marra M, Lombardi A, Agostinelli E, Giuberti G, Zappavigna S, Tempera G, et al. Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress. Biochim Biophys Acta. 2008;1783:2269-78 pubmed 出版商
Morishima Y, Wang A, Yu Z, Pratt W, Osawa Y, Lieberman A. CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet. 2008;17:3942-52 pubmed 出版商
Eder K, Leutenegger C, Köhler H, Werner I. Effects of neurotoxic insecticides on heat-shock proteins and cytokine transcription in Chinook salmon (Oncorhynchus tshawytscha). Ecotoxicol Environ Saf. 2009;72:182-90 pubmed 出版商
Stahl M, Retzlaff M, Nassal M, Beck J. Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. Nucleic Acids Res. 2007;35:6124-36 pubmed
Chen S, Brown I. Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases. Cell Stress Chaperones. 2007;12:51-8 pubmed
产品信息
产品编号 :
ADI-SPA-830
目录代码 :
ADI-SPA-830-J
产品名称 :
HSP90单克隆抗体(AC88)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
1毫克
标价(美元) :
1587美元
Pubmed号列表 :
26472975, 26397425, 25659585, 25529535, 25288732, 23412384, 18848847, 18784277, 18573527, 17441507
克隆 :
AC88
抗体亚型 :
IgG1
物种活性 :
Human, Mouse, Rat, Fusobacterium nucleatum, Water mold, Sheep, Scallop, Rabbit, Porcine, Mussel, Monkey, Mycobacterium leprae, Hamster, Guinea pig, Fish, E. coli, Dog, Chicken, C. elegans, Beluga
背景 :
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
别名 :
热休克蛋白90
免疫原 :
Achlya ambisexualis (water mold) Hsp90.
缓冲液 :
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
用途 :
Detects a band of ~90kDa by Western blot.
应用摘要 :
免疫组化(PS), 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。