产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP90α单克隆抗体(9D2)
目录 :
ADI-SPA-840-D
规格 :
50微克
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
9D2
反应物种 :
人类, , 大肠杆菌
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed 出版商
  • 免疫沉淀; 人类; 图 6b
Huang Z, Zhou X, He Y, Ke X, Wen Y, Zou F, et al. Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. Sci Rep. 2016;6:38072 pubmed 出版商
  • 免疫细胞化学; 鸡; 1:100; 图 3
Zhang X, Qian Z, Zhu H, Tang S, Wu D, Zhang M, et al. HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress. Br Poult Sci. 2016;57:462-73 pubmed 出版商
  • 免疫组化-石蜡切片; 鸡; 1:50; 图 3
Zhang X, Zhu H, Qian Z, Tang S, Wu D, Kemper N, et al. The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells. J Vet Sci. 2016;17:35-44 pubmed 出版商
  • 免疫沉淀; 人类; 图 8
  • 免疫印迹; 人类; 图 7
Seidel C, Schnekenburger M, Mazumder A, Teiten M, Kirsch G, Dicato M, et al. 4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer. Biochem Pharmacol. 2016;99:31-52 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Joshi A, Barabutis N, Birmpas C, Dimitropoulou C, Thangjam G, Cherian Shaw M, et al. Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1410-9 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Riebold M, Kozany C, Freiburger L, Sattler M, Buchfelder M, Hausch F, et al. A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease. Nat Med. 2015;21:276-80 pubmed 出版商
  • 免疫印迹; 大肠杆菌; 图 2
Liu W, Landgraf R. Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains. Biochemistry. 2015;54:1493-504 pubmed 出版商
Veit G, Oliver K, Apaja P, Perdomo D, Bidaud Meynard A, Lin S, et al. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol. 2016;14:e1002462 pubmed 出版商
Zeng X, Wang H, Bai F, Zhou X, Li S, Ren L, et al. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015;172:4303-18 pubmed 出版商
Liu W, Vielhauer G, Holzbeierlein J, Zhao H, Ghosh S, Brown D, et al. KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells. Mol Pharmacol. 2015;88:121-30 pubmed 出版商
Huang T, Chen S, Han H, Li H, Huang Z, Zhang J, et al. Expression of Hsp90? and cyclin B1 were related to prognosis of esophageal squamous cell carcinoma and keratin pearl formation. Int J Clin Exp Pathol. 2014;7:1544-52 pubmed
Hunter M, O Hagan K, Kenyon A, Dhanani K, Prinsloo E, Edkins A. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PLoS ONE. 2014;9:e86842 pubmed 出版商
Knee K, Sergeeva O, King J. Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitro. Cell Stress Chaperones. 2013;18:137-44 pubmed 出版商
Solier S, Kohn K, Scroggins B, Xu W, Trepel J, Neckers L, et al. Heat shock protein 90? (HSP90?), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A. 2012;109:12866-72 pubmed 出版商
Pellegrin S, Heesom K, Satchwell T, Hawley B, Daniels G, van den Akker E, et al. Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PLoS ONE. 2012;7:e38356 pubmed 出版商
Teng Y, Ngoka L, Mei Y, Lesoon L, Cowell J. HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein. J Biol Chem. 2012;287:10051-9 pubmed 出版商
Sahu D, Zhao Z, Tsen F, Cheng C, Park R, Situ A, et al. A potentially common peptide target in secreted heat shock protein-90? for hypoxia-inducible factor-1?-positive tumors. Mol Biol Cell. 2012;23:602-13 pubmed 出版商
Kim R, Kim R, Chen W, Hu S, Shin K, Park N, et al. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. Carcinogenesis. 2008;29:2425-31 pubmed 出版商
产品信息
产品编号 :
ADI-SPA-840
目录代码 :
ADI-SPA-840-D
产品名称 :
HSP90α单克隆抗体(9D2)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
26549368, 25939977, 25619116, 24817950, 24466266, 23011926, 22753480, 22723854, 22315230, 22190738
克隆 :
9D2
抗体亚型 :
IgG2a
物种活性 :
人类, 鸡
背景 :
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
别名 :
HSP86, 热休克蛋白90α
免疫原 :
Purified Hsp90 isolated from human therapeutic orchiectomy specimens.
缓冲液 :
液体。 在PBS, pH值7.2, 含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~90kDa by Western blot.
应用摘要 :
FC, 免疫细胞化学, 免疫组化, 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。