产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP90β单克隆抗体(K3705)
目录 :
ADI-SPA-842-D
规格 :
50微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
K3705
反应物种 :
人类, 小鼠, 大鼠, 犬, 鸡, 牛
应用 :
免疫印迹, 免疫组化, 流式细胞仪
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 5
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed 出版商
  • 免疫印迹; 大鼠
Winsauer P, Filipeanu C, Weed P, Sutton J. Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ(9)-THC) on learning in female rats. Front Pharmacol. 2015;6:133 pubmed 出版商
  • 免疫印迹; 小鼠
Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, et al. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015;45:2028-41 pubmed 出版商
  • 免疫印迹; 人类; 图 s3
Morlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed 出版商
Thirstrup K, Sotty F, Montezinho L, Badolo L, Thougaard A, Kristjánsson M, et al. Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain. Pharmacol Res. 2016;104:197-205 pubmed 出版商
产品信息
产品编号 :
ADI-SPA-842
目录代码 :
ADI-SPA-842-D
产品名称 :
HSP90β单克隆抗体(K3705)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
50微克
克隆 :
K3705
抗体亚型 :
IgM
物种活性 :
人类, 小鼠, 大鼠, 羊, 猪, 仓鼠, 豚鼠, 狗, 鸡, 牛
背景 :
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
别名 :
HSP86, 热休克蛋白90β
免疫原 :
重组人类HSP90β
缓冲液 :
液体。 在盐溶液, pH值6.9, 含0.1% 叠氮化钠
用途 :
Detects a band of ~90kDa by Western blot.
应用摘要 :
免疫组化, 免疫印迹
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。