产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP90单克隆抗体(2D12)
目录 :
ADI-SPA-845-F
规格 :
200微升
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
2D12
反应物种 :
人类, 小鼠, 大鼠, 犬, 鸡, 牛
应用 :
免疫印迹, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 8
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
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Chen Y, Schnetz M, Irarrazabal C, Shen R, Williams C, Burg M, et al. Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1. Am J Physiol Renal Physiol. 2007;292:F981-92 pubmed
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Russell K, Haynes M, Caulin Glaser T, Rosneck J, Sessa W, Bender J. Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells. Effects on calcium sensitivity and NO release. J Biol Chem. 2000;275:5026-30 pubmed
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Brunt S, Perdew G, Toft D, Silver J. Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya. Cell Stress Chaperones. 1998;3:44-56 pubmed
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Garcia Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998;392:821-4 pubmed
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产品信息
产品编号 :
ADI-SPA-845
目录代码 :
ADI-SPA-845-F
产品名称 :
HSP90单克隆抗体(2D12)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
200微升
Pubmed号列表 :
17148781, 10671543, 9585181, 9580552
克隆 :
2D12
抗体亚型 :
IgM
物种活性 :
Human, Mouse, Rat, Water mold, Sheep, Rabbit, Monkey, Hamster, Guinea pig, Fish, Dog, Chicken, Bovine, Beluga
背景 :
The 90kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90α and Hsp90β, encoded by separate genes. The amino acid sequences of human and yeast Hsp90-alpha are 85% and 90% homologous to those of Hsp90β , respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell’s powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control. In this context, researchers identified key regulatory proteins as substrates of Hsp90, including steroid receptors, cell cycle kinases involved in signal transduction, and p53. Hsp90 may act as a capacitor for morphological evolution by buffering widespread variation, potentially affecting morphogenic pathways. When temperature and other stress factors compromise Drosophila Hsp90 buffering, cryptic variant expression occurs, and selection can lead to the continued expression of these traits even after Hsp90 function is restored.
别名 :
HSP86, 热休克蛋白90β
免疫原 :
天然小鼠Hsp90
缓冲液 :
液体。 在PBS, pH值7.2, 含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~90kDa by Western blot.
应用摘要 :
免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。