产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
PDI monoclonal antibody (1D3) (DyLight™ 488 conjugate)
目录 :
ADI-SPA-891-488-D
规格 :
50微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
DyLight488
克隆名称 :
1D3
反应物种 :
人类, 小鼠, 大鼠, 犬, 鸡
应用 :
免疫印迹, 流式细胞仪
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:5000; 图 1.a,b
Treacy Abarca S, Mukherjee S. Legionella suppresses the host unfolded protein response via multiple mechanisms. Nat Commun. 2015;6:7887 pubmed 出版商
  • 免疫印迹; 小鼠
McAlpine C, Bowes A, Khan M, Shi Y, Werstuck G. Endoplasmic reticulum stress and glycogen synthase kinase-3? activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:82-91 pubmed 出版商
Bolar N, Golzio C, Zivná M, Hayot G, Van Hemelrijk C, Schepers D, et al. Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Am J Hum Genet. 2016;99:174-87 pubmed 出版商
Mätlik K, Yu L, Eesmaa A, Hellman M, Lindholm P, Peränen J, et al. Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. Cell Death Dis. 2015;6:e2032 pubmed 出版商
Capuano A, Bucciotti F, Farwell K, Tippin Davis B, Mroske C, Hulick P, et al. Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease. Hum Mutat. 2016;37:84-97 pubmed 出版商
Grigaravicius P, Kaminska E, Hübner C, McKinnon P, von Deimling A, Frappart P. Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ. 2016;23:454-68 pubmed 出版商
Kelly J, Shao Q, Jagger D, Laird D. Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions. J Cell Sci. 2015;128:3947-60 pubmed 出版商
Radoshevich L, Impens F, Ribet D, Quereda J, Nam Tham T, Nahori M, et al. ISG15 counteracts Listeria monocytogenes infection. elife. 2015;4: pubmed 出版商
Kato S, Chen J, Cornog K, Zhang H, Roberts J. The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis. Am J Physiol Cell Physiol. 2015;308:C944-58 pubmed 出版商
Hyun S, Maruri Avidal L, Moss B. Topology of Endoplasmic Reticulum-Associated Cellular and Viral Proteins Determined with Split-GFP. Traffic. 2015;16:787-95 pubmed 出版商
Langer F, Spath B, Fischer C, Stolz M, Ayuk F, Kroger N, et al. Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase. Blood. 2013;121:2324-35 pubmed 出版商
Stantchev T, Paciga M, Lankford C, Schwartzkopff F, Broder C, Clouse K. Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection. Retrovirology. 2012;9:97 pubmed 出版商
Offerdahl D, Dorward D, Hansen B, Bloom M. A three-dimensional comparison of tick-borne flavivirus infection in mammalian and tick cell lines. PLoS ONE. 2012;7:e47912 pubmed 出版商
Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K. Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Cell Stress Chaperones. 2013;18:11-23 pubmed 出版商
产品信息
产品编号 :
ADI-SPA-891-488
目录代码 :
ADI-SPA-891-488-D
产品名称 :
PDI monoclonal antibody (1D3) (DyLight™ 488 conjugate)
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
DyLight™ 488
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
23315166, 23206338, 23112871
克隆 :
1D3
抗体亚型 :
IgG1
物种活性 :
Human, Mouse, Rat, Xenopus, Sheep, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Dog, Chicken, Bovine
背景 :
The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.
别名 :
P4HB, 蛋白质二硫键异构酶
免疫原 :
Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI.
缓冲液 :
液体。 在PBS, pH值7.2, 含0.09% 叠氮化钠
用途 :
Detects a band of ~58kDa by Western blot. Cited applications include immunofluorescence.
应用摘要 :
FC
储存 :
+4°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。