产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HO-1多克隆抗体
目录 :
ADI-SPA-895-D
规格 :
50微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:2000; 图 2a
Ghosh A, Abdo S, Zhao S, Wu C, Shi Y, Lo C, et al. Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice. Endocrinology. 2017;158:903-919 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed 出版商
Chen Roetling J, Regan R. Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin. J Neurochem. 2016;139:586-595 pubmed 出版商
Halin Bergström S, Nilsson M, Adamo H, Thysell E, Jernberg E, Stattin P, et al. Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth. PLoS ONE. 2016;11:e0157280 pubmed 出版商
Cao S, Zheng M, Hua Y, Chen G, Keep R, Xi G. Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage. Stroke. 2016;47:1626-31 pubmed 出版商
Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed 出版商
Deliyanti D, Lee J, Petratos S, Meyer C, Ward K, Wilkinson Berka J, et al. A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy. Clin Sci (Lond). 2016;130:1375-87 pubmed 出版商
Chen K, Huang K, Lin C, Weng W, Hsu L, Goto S, et al. MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2016;5:e285 pubmed 出版商
Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, et al. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J Biol Inorg Chem. 2016;21:263-73 pubmed 出版商
Kongpetch S, Puapairoj A, Ong C, Senggunprai L, Prawan A, Kukongviriyapan U, et al. Haem oxygenase 1 expression is associated with prognosis in cholangiocarcinoma patients and with drug sensitivity in xenografted mice. Cell Prolif. 2016;49:90-101 pubmed 出版商
Cheng T, Wang W, Li Q, Han X, Xing J, Qi C, et al. Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways. Free Radic Biol Med. 2016;92:15-28 pubmed 出版商
Barone E, Di Domenico F, Cassano T, Arena A, Tramutola A, Lavecchia M, et al. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med. 2016;91:127-42 pubmed 出版商
Lim J, van der Pol S, Di Dio F, Van het Hof B, Kooij G, de Vries H, et al. Protective effects of monomethyl fumarate at the inflamed blood-brain barrier. Microvasc Res. 2016;105:61-9 pubmed 出版商
Kang L, Grande J, Hillestad M, Croatt A, Barry M, Katusic Z, et al. A new model of an arteriovenous fistula in chronic kidney disease in the mouse: beneficial effects of upregulated heme oxygenase-1. Am J Physiol Renal Physiol. 2016;310:F466-76 pubmed 出版商
产品信息
产品编号 :
ADI-SPA-895
目录代码 :
ADI-SPA-895-D
产品名称 :
HO-1多克隆抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
26724590, 26698666, 26679389, 26296046, 26238177, 26237274, 26071936, 25667042, 25148934, 25054000
图像4 :
Immunohistochemistry analysis of human spleen tissue stained with HO-1, pAb at 10µg/ml.
物种活性 :
人类, 小鼠, 大鼠, 羊, 兔, 狗
背景 :
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
别名 :
HMOX1, Hsp32, 热休克蛋白32, 血红素氧化酶
免疫原 :
Recombinant rat HO-1 (Hsp32) lacking the membrane spanning region.
缓冲液 :
液体。 在PBS含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~32kDa by Western blot.
应用摘要 :
FC, 免疫细胞化学, 免疫组化(PS), 免疫印迹
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。