产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HO-1多克隆抗体
目录 :
ADI-SPA-896-D
规格 :
50微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 s1a
Chen C, Wang S, Yu L, Mueller J, Fortunato F, Rausch V, et al. H2O2-mediated autophagy during ethanol metabolism. Redox Biol. 2021;46:102081 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5b
Krzeptowski W, Chudy P, Sokołowski G, Zukowska M, Kusienicka A, Seretny A, et al. Proximity Ligation Assay Detection of Protein-DNA Interactions-Is There a Link between Heme Oxygenase-1 and G-quadruplexes?. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 2a
Detsika M, Myrtsi E, Koulocheri S, Haroutounian S, Lianos E, Roussos C. Induction of decay accelerating factor and membrane cofactor protein by resveratrol attenuates complement deposition in human coronary artery endothelial cells. Biochem Biophys Rep. 2019;19:100652 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Inouye S, Hatori Y, Kubo T, Saito S, Kitamura H, Akagi R. NRF2 and HSF1 coordinately regulate heme oxygenase-1 expression. Biochem Biophys Res Commun. 2018;506:7-11 pubmed 出版商
Scharn C, Collins A, Nair V, Stamm C, MARCIANO D, Graviss E, et al. Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection. J Immunol. 2016;196:4641-9 pubmed 出版商
Oh S, Hwang J, Lee Y, Choi S, Kim J, Kim J, et al. Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies. Placenta. 2016;39:24-32 pubmed 出版商
Marques L, Negre Salvayre A, Costa L, Canonne Hergaux F. Iron gene expression profile in atherogenic Mox macrophages. Biochim Biophys Acta. 2016;1862:1137-46 pubmed 出版商
van den Bosch T, Boichenko A, Leus N, Ourailidou M, Wapenaar H, Rotili D, et al. The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases. Biochem Pharmacol. 2016;102:130-140 pubmed 出版商
Mercau M, Repetto E, Perez M, Martinez Calejman C, Sánchez Puch S, Finkielstein C, et al. Moderate Exercise Prevents Functional Remodeling of the Anterior Pituitary Gland in Diet-Induced Insulin Resistance in Rats: Role of Oxidative Stress and Autophagy. Endocrinology. 2016;157:1135-45 pubmed 出版商
Mohammed B, Fisher B, Kraskauskas D, Ward S, Wayne J, Brophy D, et al. Vitamin C promotes wound healing through novel pleiotropic mechanisms. Int Wound J. 2016;13:572-84 pubmed 出版商
产品信息
产品编号 :
ADI-SPA-896
目录代码 :
ADI-SPA-896-D
产品名称 :
HO-1多克隆抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
26718586, 26672805, 26330549, 26165190, 25753484, 21697243, 19617415, 18846504, 12588181, 12395150
物种活性 :
Human, Mouse, Rat, Rabbit, Monkey, Hamster, Dog
背景 :
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
别名 :
HMOX1, Hsp32, 热休克蛋白32, 血红素氧化酶
免疫原 :
Synthetic peptide corresponding to the sequence near the N-terminus of human HO-1.
缓冲液 :
液体。 在PBS含50% 甘油和0.09% 叠氮化钠
用途 :
Detects a band of ~32kDa by Western blot.
应用摘要 :
免疫组化(PS), 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。