产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
HSP90α多克隆抗体
目录 :
ADI-SPS-771-D
规格 :
50微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬, 牛
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 3
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 6a
  • 免疫印迹; 人类; 图 5a
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed 出版商
Saito Y, Akazawa Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, et al. Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients. Sci Rep. 2016;6:30793 pubmed 出版商
Gaponova A, Nikonova A, Deneka A, Kopp M, Kudinov A, Skobeleva N, et al. A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. Clin Cancer Res. 2016;22:5120-5129 pubmed 出版商
产品信息
产品编号 :
ADI-SPS-771
目录代码 :
ADI-SPS-771-D
产品名称 :
HSP90α多克隆抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
抗体
规格 :
50微克
Pubmed号列表 :
17360691, 17304217, 11160250
物种活性 :
Human, Mouse, Rat, Xenopus, Sheep, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Fish, Dog, Bovine, Beluga
背景 :
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
别名 :
HSP86, 热休克蛋白90α
免疫原 :
Synthetic peptide corresponding to a portion of mouse Hsp86.
缓冲液 :
液体。 在PBS含0.09% 叠氮化钠和50% 甘油
用途 :
Detects a band of ~90kDa by Western blot.
应用摘要 :
IHC, WB, Inhibition assay, Cell migration
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。