产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
蛋白
产品名称 :
胱氨酸-天冬氨酸蛋白酶9(人类),(重组)(活性的)
目录 :
ALX-201-047-U100
规格 :
100 U
更多信息或购买 :
文章摘录数: 6
参考文献
McMillan E, Quadrilatero J. Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles. Am J Physiol Regul Integr Comp Physiol. 2011;300:R531-43 pubmed 出版商
Srinivasula S, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001;410:112-6 pubmed
Pan G, O Rourke K, Dixit V. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem. 1998;273:5841-5 pubmed
Li P, Nijhawan D, Budihardjo I, Srinivasula S, Ahmad M, Alnemri E, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-89 pubmed
Srinivasula S, Fernandes Alnemri T, Zangrilli J, Robertson N, Armstrong R, Wang L, et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996;271:27099-106 pubmed
Duan H, Orth K, Chinnaiyan A, Poirier G, Froelich C, He W, et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996;271:16720-4 pubmed
产品信息
产品编号 :
ALX-201-047
目录代码 :
ALX-201-047-U100
产品名称 :
胱氨酸-天冬氨酸蛋白酶9(人类),(重组)(活性的)
产品类型 :
蛋白
规格 :
100 U
Pubmed号列表 :
21148478, 11242052, 9488720, 9390557, 8900201, 8663294
背景 :
Caspase-9 (also known as Ice-Lap6 and Mch6) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-9 also exists in cells as an inactive proenzyme. During the initiation of apoptosis procaspase-9 is processed at aspartate residues to form active caspase-9. As one of the initiator caspases, active caspase-9 functions to trigger the activation of downstream effector caspases, leading to disassembly of cell structures. The active recombinant caspase-9 is routinely tested for its ability to enzymatically cleave the caspase-9 colorimetric substrate Ac-LEHD-pNA (Prod. No. ALX-260-081).
别名 :
ICE-LAP-6, Mch6
纯度 :
≥90%(十二烷基磺酸钠-PAGE)
缓冲液 :
冻干
用途 :
Useful in screening caspase inhibitors, studying enzyme regulation, determining target substrates or as positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.
储存 :
-80°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。