产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Deguelin
目录 :
ALX-350-118-M005
规格 :
5毫克
更多信息或购买 :
文章摘录数: 7
| 参考文献 |
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Lee H. Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol. 2004;68:1119-24 pubmed
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Hail N, Lotan R. Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics. Apoptosis. 2004;9:437-47 pubmed
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Lee H, Suh Y, Kosmeder J, Pezzuto J, Hong W, Kurie J. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res. 2004;10:1074-9 pubmed
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Ito C, Itoigawa M, Kojima N, Tan H, Takayasu J, Tokuda H, et al. Cancer chemopreventive activity of rotenoids from Derris trifoliata. Planta Med. 2004;70:8-11 pubmed
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Chun K, Kosmeder J, Sun S, Pezzuto J, Lotan R, Hong W, et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst. 2003;95:291-302 pubmed
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Murillo G, Salti G, Kosmeder J, Pezzuto J, Mehta R. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer. 2002;38:2446-54 pubmed
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Udeani G, Gerhauser C, Thomas C, Moon R, Kosmeder J, Kinghorn A, et al. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 1997;57:3424-8 pubmed
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产品信息
产品编号 :
ALX-350-118
目录代码 :
ALX-350-118-M005
产品名称 :
Deguelin
产品类型 :
Biochemical
规格 :
5毫克
Pubmed号列表 :
15313408, 15192326, 14871987, 14765285, 12591985, 12460790, 9270008
产品描述 :
Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.
别名 :
[-]-Deguelin
纯度 :
≥95%(HPLC)
储存 :
+4°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。