产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Betulinic acid (high purity)
目录 :
ALX-350-277-M005
规格 :
5毫克
更多信息或购买 :
文章摘录数: 10
参考文献
Huang L, Ho P, Chen C. Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS Lett. 2007;581:4955-9 pubmed
Wada S, Tanaka R. Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica. Chem Biodivers. 2005;2:689-94 pubmed
Poeckel D, Tausch L, Altmann A, Feisst C, Klinkhardt U, Graff J, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005;146:514-24 pubmed
Kasperczyk H, La Ferla Brühl K, Westhoff M, Behrend L, Zwacka R, Debatin K, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005;24:6945-56 pubmed
Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem. 2005;12:657-66 pubmed
Syrovets T, Gschwend J, Büchele B, Laumonnier Y, Zugmaier W, Genze F, et al. Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. J Biol Chem. 2005;280:6170-80 pubmed
Cichewicz R, Kouzi S. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2004;24:90-114 pubmed
Takada Y, Aggarwal B. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol. 2003;171:3278-86 pubmed
Selzer E, Pimentel E, Wacheck V, Schlegel W, Pehamberger H, Jansen B, et al. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J Invest Dermatol. 2000;114:935-40 pubmed
Fulda S, Jeremias I, Steiner H, Pietsch T, Debatin K. Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells. Int J Cancer. 1999;82:435-41 pubmed
产品信息
产品编号 :
ALX-350-277
目录代码 :
ALX-350-277-M005
产品名称 :
Betulinic acid (high purity)
产品类型 :
Biochemical
规格 :
5毫克
Pubmed号列表 :
17904555, 17192012, 16086030, 16007147, 15790304, 15576374, 14595673, 12960358, 10771474, 10399962
产品描述 :
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Triggers CD95- and p53-independent apoptosis via activation of caspases. It induces mitochondrial permeability pore opening and the release of cytochrome c and apoptosis-inducing factor. Displays anti-HIV activity. EC50 for inhibion of HIV-1 replicaton in H9 lymphocytes: 1.4µM.
别名 :
3β-Hydroxy-20(29)-lupaene-28-oic acid
纯度 :
≥97%(HPLC)
储存 :
+4°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。