产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Purmorphamine
目录 :
ALX-420-045-M025
规格 :
25毫克
更多信息或购买 :
文章摘录数: 6
参考文献
Ehrlich M, Hallmann A, Reinhardt P, Araúzo Bravo M, Korr S, Röpke A, et al. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports. 2015;5:83-96 pubmed 出版商
Figeac F, Dagouassat M, Mahrouf Yorgov M, le Gouvello S, Trébeau C, Sayed A, et al. Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway. PLoS ONE. 2015;10:e0121579 pubmed 出版商
Sinha S, Chen J. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006;2:29-30 pubmed
Beloti M, Bellesini L, Rosa A. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005;29:537-41 pubmed
Wu X, Walker J, Zhang J, Ding S, Schultz P. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol. 2004;11:1229-38 pubmed
Wu X, Ding S, Ding Q, Gray N, Schultz P. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc. 2002;124:14520-1 pubmed
产品信息
产品编号 :
ALX-420-045
目录代码 :
ALX-420-045-M025
产品名称 :
Purmorphamine
产品类型 :
Biochemical
规格 :
25毫克
Pubmed号列表 :
26143746, 25815884, 16408088, 15979909, 15380183, 12465946
产品描述 :
Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.
别名 :
2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
纯度 :
≥98%(HPLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。