产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
RITA
目录 :
ALX-430-151-M001
规格 :
1毫克
更多信息或购买 :
文章摘录数: 4
参考文献
Krajewski M, Ozdowy P, D Silva L, Rothweiler U, Holak T. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat Med. 2005;11:1135-6; author reply 1136-7 pubmed
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef L, Masucci M, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004;10:1321-8 pubmed
Nieves Neira W, Rivera M, Kohlhagen G, Hursey M, Pourquier P, Sausville E, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999;56:478-84 pubmed
Rivera M, Stinson S, Vistica D, Jorden J, Kenney S, Sausville E. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem Pharmacol. 1999;57:1283-95 pubmed
产品信息
产品编号 :
ALX-430-151
目录代码 :
ALX-430-151-M001
产品名称 :
RITA
产品类型 :
Biochemical
规格 :
1毫克
Pubmed号列表 :
16270059, 15558054, 10462535, 10230772
产品描述 :
Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53.
别名 :
Reactivation of p53 and Induction of Tumor Cell Apoptosis, 2,5-bis(5-Hydroxymethyl-2-thienyl)furan, NSC652287
纯度 :
≥98%(HPLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。