产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Tranilast
目录 :
ALX-550-409-M010
规格 :
10毫克
更多信息或购买 :
文章摘录数: 9
参考文献
Petrilli J, Wadsworth S, Cooper K, Rodgers K, Siekierka J, diZerega G. Tranilast: a pharmaceutical candidate for reduction of adhesions using a novel approach. Semin Reprod Med. 2008;26:341-8 pubmed 出版商
Platten M, Ho P, Youssef S, Fontoura P, Garren H, Hur E, et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science. 2005;310:850-5 pubmed
Namazi M, Soma J. Tranilast: a novel weapon against insulin resistance. Med Hypotheses. 2005;64:1135-7 pubmed
Spiecker M, Lorenz I, Marx N, Darius H. Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells. Mol Pharmacol. 2002;62:856-63 pubmed
Chikaraishi A, Hirahashi J, Takase O, Marumo T, Hishikawa K, Hayashi M, et al. Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells. Eur J Pharmacol. 2001;427:151-8 pubmed
Takahashi A, Taniguchi T, Ishikawa Y, Yokoyama M. Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21(waf1/cip1/sdi1) and p53. Circ Res. 1999;84:543-50 pubmed
Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol. 1997;122:1061-6 pubmed
Yamada H, Tajima S, Nishikawa T, Murad S, Pinnell S. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 1994;116:892-7 pubmed
Suzawa H, Kikuchi S, Ichikawa K, Koda A. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol. 1992;60:85-90 pubmed
产品信息
产品编号 :
ALX-550-409
目录代码 :
ALX-550-409-M010
产品名称 :
Tranilast
产品类型 :
Biochemical
规格 :
10毫克
Pubmed号列表 :
18756411, 16272121, 16272121, 15823702, 12237332, 11557268, 10082476, 9401770, 7533764, 1282575
产品描述 :
Anti-inflammatory and anti-angiogenic agent. Inhibits VEGF-induced angiogenesis in vivo . Inhibits proliferation and tube formation of human endothelial cells in vitro. Also inhibits smooth muscle cell proliferation and prevents post-angiplasty retsenosis.Synthetic compound with structural similarity to the tryptophan (Trp) catabolites kynurenines. Tranilast ameliorates the disease severity in animal models of multiple sclerosis, in part, by inducing T cell tolerance. Trp degradation is an important mechanism in the maintenance of T cell tolerance in a variety of disease models and is mediated by the rate limiting enzyme indoleamine 2,3-dioxygenase (IDO).
别名 :
N-(3’,4’-Dimethoxycinnamoyl)anthranilic acid, 3,4-DAA
纯度 :
≥95%(HPLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。