产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
肿瘤坏死因子-R1(人类)单克隆抗体(H398)
目录 :
ALX-804-200-C100
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
H398
反应物种 :
人类
应用 :
免疫组化, 流式细胞仪
更多信息或购买 :
文章摘录数: 11
| 参考文献 |
|---|
Gajate C, Mollinedo F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005;280:11641-7 pubmed
|
Lu G, Janjic B, Janjic J, Whiteside T, Storkus W, Vujanovic N. Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. J Immunol. 2002;168:1831-9 pubmed
|
Horie T, Dobashi K, Iizuka K, Yoshii A, Shimizu Y, Nakazawa T, et al. Interferon-gamma rescues TNF-alpha-induced apoptosis mediated by up-regulation of TNFR2 on EoL-1 cells. Exp Hematol. 1999;27:512-9 pubmed
|
Tang D, Lahti J, Grenet J, Kidd V. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J Biol Chem. 1999;274:7245-52 pubmed
|
Choi K, Wong F, Harlan J, Chaudhary P, Hood L, Karsan A. Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway. J Biol Chem. 1998;273:20185-8 pubmed
|
Geilen C, Bektas M, Wieder T, Kodelja V, Goerdt S, Orfanos C. 1alpha,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alpha. J Biol Chem. 1997;272:8997-9001 pubmed
|
Weigert N, Schaffer K, Schusdziarra V, Classen M, Schepp W. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Gastroenterology. 1996;110:147-54 pubmed
|
Grell M, Scheurich P, Meager A, Pfizenmaier K. TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis. Lymphokine Cytokine Res. 1993;12:143-8 pubmed
|
Pagliacci M, Fumi G, Migliorati G, Grignani F, Riccardi C, Nicoletti I. Cytostatic and cytotoxic effects of tumor necrosis factor alpha on MCF-7 human breast tumor cells are differently inhibited by glucocorticoid hormones. Lymphokine Cytokine Res. 1993;12:439-47 pubmed
|
Gibbons D, Rowe M, Cope A, Feldmann M, Brennan F. Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines. Eur J Immunol. 1994;24:1879-85 pubmed
|
产品信息
产品编号 :
ALX-804-200
目录代码 :
ALX-804-200-C100
产品名称 :
肿瘤坏死因子-R1(人类)单克隆抗体(H398)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
Pubmed号列表 :
15659383, 11823516, 10089914, 10066786, 9685365, 9083023, 8536851, 8394147, 8123760, 8056047
克隆 :
H398
抗体亚型 :
IgG2a
物种活性 :
人类
别名 :
肿瘤坏死因子-R 60kDa, CD120a, p55, TNFRSF 1A
免疫原 :
人类肿瘤坏死因子-R1
特异性 :
Recognizes membrane-bound and soluble TNF-R1.
缓冲液 :
液体。 在PBS
用途 :
Not recommended for IHC (PS). Functional Application: blocks TNF-R signalling. 10µg/ml H398 neutralizes TNF induced cytotoxicity on U937 (100%). Furthermore, 10µg/ml H398 neutralizes TNF induced MHC expression on K562, Colo 205 and IL2R on YT cells (always 100%). TNF induced cytotoxicity can be inhibited/neutralized by H398 on MCF-7, HeLa and L929. A working concentration could not be determined, since ascites antibody preparations have been used which exhibit an unspecific cytotoxic effect on the cells. Functional activity via the TNF-R1 is completely inhibited by H398 although on some cells the ligand still binds. Thus, the antibody H398 inhibits signalling via the receptor but not always the binding of TNF.
应用摘要 :
FC, 免疫组化(FS), FUNC
储存 :
+4°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。