产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
PARP-1单克隆抗体(F1-23)
目录 :
ALX-804-211-R050
规格 :
50微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
F1-23
反应物种 :
人类, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 11
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 5a
Slyskova J, Sabatella M, Ribeiro Silva C, Stok C, Theil A, Vermeulen W, et al. Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage. Nucleic Acids Res. 2018;46:9537-9549 pubmed 出版商
  • 免疫沉淀; 人类
Rossi M, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, et al. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity. J Biol Chem. 2009;284:31616-24 pubmed 出版商
Zilio N, Williamson C, Eustermann S, Shah R, West S, Neuhaus D, et al. DNA-dependent SUMO modification of PARP-1. DNA Repair (Amst). 2013;12:761-73 pubmed 出版商
Ouararhni K, Hadj Slimane R, Ait Si Ali S, Robin P, Mietton F, Harel Bellan A, et al. The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity. Genes Dev. 2006;20:3324-36 pubmed
Augustin A, Spenlehauer C, Dumond H, Menissier de Murcia J, Piel M, Schmit A, et al. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. J Cell Sci. 2003;116:1551-62 pubmed
Duriez P, Desnoyers S, Hoflack J, Shah G, Morelle B, Bourassa S, et al. Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase. Biochim Biophys Acta. 1997;1334:65-72 pubmed
Chinnaiyan A, Tepper C, Seldin M, O Rourke K, Kischkel F, Hellbardt S, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem. 1996;271:4961-5 pubmed
Kaufmann S, Desnoyers S, Ottaviano Y, Davidson N, Poirier G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993;53:3976-85 pubmed
Lazebnik Y, Kaufmann S, Desnoyers S, Poirier G, Earnshaw W. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371:346-7 pubmed
Lazebnik Y, Takahashi A, Moir R, Goldman R, Poirier G, Kaufmann S, et al. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A. 1995;92:9042-6 pubmed
Lamarre D, Talbot B, de Murcia G, Laplante C, Leduc Y, Mazen A, et al. Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. Biochim Biophys Acta. 1988;950:147-60 pubmed
产品信息
产品编号 :
ALX-804-211
目录代码 :
ALX-804-211-R050
产品名称 :
PARP-1单克隆抗体(F1-23)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
50微升
Pubmed号列表 :
23871147, 17158748, 12640039, 9042367, 8617770, 8358726, 8090205, 7568069, 2454668
克隆 :
F1-23
抗体亚型 :
IgG1
物种活性 :
人类, 牛
别名 :
Poly(ADP-ribose) polymerase-1
免疫原 :
Purified bovine PARP-1 (poly(ADP-ribose) polymerase-1).
特异性 :
Recognizes an epitope in the zinc finger II DNA binding domain of PARP-1.
缓冲液 :
Liquid. Ascites fluid containing 0.02% sodium azide.
用途 :
Detects bands of ~116kDa (intact PARP-1) and ~24kDa (apoptosis-induced cleavage fragment) by Western blot. Functional Application: neutralizes the biological activity of PARP (~80%).
应用摘要 :
酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 免疫印迹, FUNC, ChIP
储存 :
-80°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。