产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
囊性纤维化跨膜电导调节因子单克隆抗体(CF3)
目录 :
ALX-804-214-R100
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CF3
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 2
| 参考文献 |
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Xu W, Shi Q, Chen W, Zhou C, Ni Y, Rowlands D, et al. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proc Natl Acad Sci U S A. 2007;104:9816-21 pubmed
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Walker J, Watson J, Holmes C, Edelman A, Banting G. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci. 1995;108 ( Pt 6):2433-44 pubmed
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产品信息
产品编号 :
ALX-804-214
目录代码 :
ALX-804-214-R100
产品名称 :
囊性纤维化跨膜电导调节因子单克隆抗体(CF3)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微升
Pubmed号列表 :
17519339, 7545688
克隆 :
CF3
抗体亚型 :
IgM
物种活性 :
人类, 小鼠
背景 :
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (δ F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
别名 :
囊性纤维化跨膜电导调节器, ABCC7
免疫原 :
Synthetic peptide corresponding to aa 103-117(G103RIIASYDPDNKEER117) in the first extracellular loop of human and rabbit CFTR (cystic fibrosis transmembrane conductance regulator). This sequence is highly conserved in mouse, sheep, bovine and Xenopus laevis CFTR.
缓冲液 :
Liquid. Diluted ascites containing 0.05% sodium azide.
用途 :
Detects a band of ~170kDa by Western blot. Functional Application: inhibits epithelial uptake of S. typhi in some mouse cell lines.
应用摘要 :
免疫细胞化学, 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。