产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶8(人类)单克隆抗体(12F5)
目录 :
ALX-804-242-C100
规格 :
100微克
价格 :
381美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
12F5
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 2j
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed 出版商
  • 免疫印迹; 人类; 图 8c
Lee S, North K, Kim E, Jang E, Obeng E, Lu S, et al. Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations. Cancer Cell. 2018;34:225-241.e8 pubmed 出版商
  • 免疫印迹; 人类; 图 s3d
Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Weyhenmeyer B, Noonan J, Würstle M, Lincoln F, Johnston G, Rehm M, et al. Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget. 2016;7:61295-61311 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Moriwaki K, Chan F. Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. J Biol Chem. 2016;291:5948-59 pubmed 出版商
  • 免疫沉淀; 人类; 图 2
  • 免疫印迹; 人类; 图 2
Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, et al. Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death Dis. 2016;7:e2052 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Cousin F, Jouan Lanhouet S, Théret N, Brenner C, Jouan E, Le Moigne Muller G, et al. The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. Oncotarget. 2016;7:7161-78 pubmed 出版商
  • 免疫细胞化学; 人类; 图 8a
Salva K, Wood G. Epigenetically Enhanced Photodynamic Therapy (ePDT) is Superior to Conventional Photodynamic Therapy for Inducing Apoptosis in Cutaneous T-Cell Lymphoma. Photochem Photobiol. 2015;91:1444-51 pubmed 出版商
  • 免疫印迹; 人类
Moriwaki K, Shinzaki S, Miyoshi E. GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. J Biol Chem. 2011;286:43123-33 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ashley D, Riffkin C, Lovric M, Mikeska T, Dobrovic A, Maxwell J, et al. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. Br J Cancer. 2008;99:294-304 pubmed 出版商
  • 免疫印迹; 人类
Strauss G, Westhoff M, Fischer Posovszky P, Fulda S, Schanbacher M, Eckhoff S, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008;15:332-43 pubmed
Bartee M, Dunlap K, Bartee E. Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells. Clin Lymphoma Myeloma Leuk. 2016;16:203-12 pubmed 出版商
de Almagro M, Goncharov T, Newton K, Vucic D. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination. Cell Death Dis. 2015;6:e1800 pubmed 出版商
Kaemmerer E, Kuhn P, Schneider U, Jeon M, Klaus C, Schiffer M, et al. Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes. World J Gastroenterol. 2015;21:4499-508 pubmed 出版商
Nagel S, Keuper M, Zagotta I, Enlund E, Ruperez A, Debatin K, et al. Up-regulation of Bcl-2 during adipogenesis mediates apoptosis resistance in human adipocytes. Mol Cell Endocrinol. 2014;382:368-376 pubmed 出版商
Riley J, Hutchinson R, McArt D, Crawford N, Holohan C, Paul I, et al. Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer. Cell Death Dis. 2013;4:e951 pubmed 出版商
Conus S, Pop C, Snipas S, Salvesen G, Simon H. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem. 2012;287:21142-51 pubmed 出版商
Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, et al. The role of c-FLIP splice variants in urothelial tumours. Cell Death Dis. 2011;2:e245 pubmed 出版商
Hurwitz J, Stasik I, Kerr E, Holohan C, Redmond K, McLaughlin K, et al. Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent. Eur J Cancer. 2012;48:1096-107 pubmed 出版商
Geering B, Gurzeler U, Federzoni E, Kaufmann T, Simon H. A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils. Blood. 2011;117:5953-62 pubmed 出版商
Gillissen B, Wendt J, Richter A, Richter A, Müer A, Overkamp T, et al. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. J Cell Biol. 2010;188:851-62 pubmed 出版商
Rebsamen M, Meylan E, Curran J, Tschopp J. The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ. 2008;15:1804-11 pubmed 出版商
Goval J, Thielen C, Bourguignon C, Greimers R, Dejardin E, Choi Y, et al. The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. Haematologica. 2008;93:1169-77 pubmed 出版商
产品信息
产品编号 :
ALX-804-242
目录代码 :
ALX-804-242-C100
产品名称 :
胱氨酸-天冬氨酸蛋白酶8(人类)单克隆抗体(12F5)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
标价(美元) :
381美元
Pubmed号列表 :
26111062, 25914458, 24397922, 24309938, 22528489, 22154545, 22027835, 21478427, 20308427, 18756281
克隆 :
12F5
抗体亚型 :
IgG2b
物种活性 :
人类
别名 :
FLICE
免疫原 :
重组人类胱氨酸-天冬氨酸蛋白酶8
特异性 :
Recognizes procaspase-8 and active caspase-8. Detects procaspase-8 (p55/54), the intermediate cleavage products (p43/41) and the p18 active subunit of caspase-8 by Western blot.
缓冲液 :
液体。 在0.15M PBS, pH值7.2, 含1% BSA和0.01% 硫柳汞
应用摘要 :
免疫组化(FS), 免疫沉淀, 免疫印迹
储存 :
+4°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。