产品简要
信息索取 :
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
α-Synuclein (human) monoclonal antibody (15G7)
目录 :
ALX-804-258-LC05
规格 :
0.5毫升
价格 :
201美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
nonconjugated
克隆名称 :
15G7
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, immunohistochemistry - free floating section
更多信息或购买 :
文章摘录数: 25
已发表的文献中的应用方法/种属/稀释度 | 参考文献 |
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Sturm E, Fellner L, Krismer F, Poewe W, Wenning G, Stefanova N. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy. Neurotherapeutics. 2016;13:871-879 pubmed
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Mosharov E, Staal R, Bove J, Prou D, Hananiya A, Markov D, et al. Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci. 2006;26:9304-11 pubmed
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产品信息
产品编号 :
ALX-804-258
目录代码 :
ALX-804-258-LC05
产品名称 :
α-Synuclein (human) monoclonal antibody (15G7)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
0.5毫升
标价(美元) :
201美元
Pubmed号列表 :
26620202, 26496712, 23936403, 23691255, 23426727, 23108585, 22647715, 20152114, 18195271, 16957086
克隆 :
15G7
抗体亚型 :
IgG2a
物种活性 :
人类
背景 :
Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being a-synuclein (a-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: b-synuclein, g-synuclein, and synoretin. a-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to a-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that a-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase. ARSs only account for a small percentage of NSD. Thus the illustration that a-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of a-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, a-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for a-SYN inclusions in all forms of NSDs.
免疫原 :
Synthetic peptide corresponding to aa 116-131 of human α-synuclein.
缓冲液 :
Liquid. Hybridoma supernatant containing 0.05% sodium azide.
应用摘要 :
免疫组化(FS), 免疫组化(PS), 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。
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