产品简要
信息索取 :
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
α-Synuclein (human) monoclonal antibody (15G7)
目录 :
ALX-804-258-LC05
规格 :
0.5毫升
价格 :
201美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
nonconjugated
克隆名称 :
15G7
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, immunohistochemistry - free floating section
更多信息或购买 :
文章摘录数: 25
已发表的文献中的应用方法/种属/稀释度参考文献
  • 免疫印迹; 人类; 图 1
  • 免疫细胞化学; 人类; 图 5
  • 免疫组化; 人类; 1:100; 图 1
Sommer A, Fadler T, Dorfmeister E, Hoffmann A, Xiang W, Winner B, et al. Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model. J Neuroinflammation. 2016;13:174 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Van Rompuy A, Oliveras-Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V. Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration. Mol Neurodegener. 2015;10:23 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:20; 图 5
Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, et al. Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model. BMC Neurosci. 2013;14:6 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 1:200
  • 免疫细胞化学; 人类; 1:100
Aelvoet S, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, et al. Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters. J Neurosci. 2014;34:16518-32 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200
Krismer F, Wenning G, Li Y, Poewe W, Stefanova N. Intact olfaction in a mouse model of multiple system atrophy. PLoS ONE. 2013;8:e64625 pubmed 出版商
  • 免疫印迹; 人类; 1:30; 图 5
  • 免疫细胞化学; 人类; 1:200; 图 2
Ettle B, Reiprich S, Deusser J, Schlachetzki J, Xiang W, Prots I, et al. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Mol Cell Neurosci. 2014;62:68-78 pubmed 出版商
Rabl R, Breitschaedel C, Flunkert S, Duller S, Amschl D, Neddens J, et al. Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice. BMC Neurosci. 2017;18:22 pubmed 出版商
Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, et al. High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease. J Neurosci Methods. 2016;261:117-27 pubmed 出版商
Fellner L, Kuzdas-Wood D, Levin J, Ryazanov S, Leonov A, Griesinger C, et al. Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy. Front Neurosci. 2016;10:99 pubmed 出版商
Ettle B, Kerman B, Valera E, Gillmann C, Schlachetzki J, Reiprich S, et al. α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016;132:59-75 pubmed 出版商
Sturm E, Fellner L, Krismer F, Poewe W, Wenning G, Stefanova N. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy. Neurotherapeutics. 2016;13:871-879 pubmed
Kohl Z, Ben Abdallah N, Vogelgsang J, Tischer L, Deusser J, Amato D, et al. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Neurobiol Dis. 2016;85:206-17 pubmed 出版商
Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, et al. Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications. PLoS ONE. 2016;11:e0150705 pubmed 出版商
Xiang W, Menges S, Schlachetzki J, Meixner H, Hoffmann A, Schlötzer-Schrehardt U, et al. Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Mol Neurodegener. 2015;10:8 pubmed 出版商
Deusser J, Schmidt S, Ettle B, Plötz S, Huber S, Müller C, et al. Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease. J Neurochem. 2015;135:589-97 pubmed 出版商
Kuzdas-Wood D, Fellner L, Premstaller M, Borm C, Bloem B, Kirik D, et al. Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity. BMC Neurosci. 2015;16:86 pubmed 出版商
Aldecoa I, Navarro-Otano J, Stefanova N, Sprenger F, Seppi K, Poewe W, et al. Alpha-synuclein immunoreactivity patterns in the enteric nervous system. Neurosci Lett. 2015;602:145-9 pubmed 出版商
Kuzdas-Wood D, Irschick R, Theurl M, Malsch P, Mair N, Mantinger C, et al. Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype. PLoS ONE. 2015;10:e0136575 pubmed 出版商
Obi T, Nishioka K, Ross O, Terada T, Yamazaki K, Sugiura A, et al. Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia. Neurology. 2008;70:238-41 pubmed 出版商
Boudes M, Uvin P, Pinto S, Voets T, Fowler C, Wenning G, et al. Bladder dysfunction in a transgenic mouse model of multiple system atrophy. Mov Disord. 2013;28:347-55 pubmed 出版商
Nemani V, Lu W, Berge V, Nakamura K, Onoa B, Lee M, et al. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010;65:66-79 pubmed 出版商
Klucken J, Poehler A, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, et al. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 2012;8:754-66 pubmed 出版商
Paumier K, Sukoff Rizzo S, Berger Z, Chen Y, Gonzales C, Kaftan E, et al. Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease. PLoS ONE. 2013;8:e70274 pubmed 出版商
Mosharov E, Staal R, Bove J, Prou D, Hananiya A, Markov D, et al. Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci. 2006;26:9304-11 pubmed
Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, et al. Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia. 2013;61:349-60 pubmed 出版商
产品信息
产品编号 :
ALX-804-258
目录代码 :
ALX-804-258-LC05
产品名称 :
α-Synuclein (human) monoclonal antibody (15G7)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
0.5毫升
标价(美元) :
201美元
Pubmed号列表 :
26620202, 26496712, 23936403, 23691255, 23426727, 23108585, 22647715, 20152114, 18195271, 16957086
克隆 :
15G7
抗体亚型 :
IgG2a
物种活性 :
人类
背景 :
Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being a-synuclein (a-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: b-synuclein, g-synuclein, and synoretin. a-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to a-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that a-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase. ARSs only account for a small percentage of NSD. Thus the illustration that a-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of a-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, a-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for a-SYN inclusions in all forms of NSDs.
免疫原 :
Synthetic peptide corresponding to aa 116-131 of human α-synuclein.
缓冲液 :
Liquid. Hybridoma supernatant containing 0.05% sodium azide.
应用摘要 :
免疫组化(FS), 免疫组化(PS), 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。