产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶2单克隆抗体(11B4)
目录 :
ALX-804-356-C100
规格 :
100微克
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
11B4
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫沉淀, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 18
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 3
Jelinek M, Kabelova A, Srámek J, Seitz J, Ojima I, Kovar J. Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells. Anticancer Res. 2017;37:1581-1590 pubmed
  • 免疫印迹基因敲除验证; 小鼠; 图 1
Lopez Cruzan M, Sharma R, Tiwari M, Karbach S, Holstein D, Martin C, et al. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov. 2016;2: pubmed
  • 免疫印迹; 人类; 图 2d
Yang C, Matsuura K, Huang N, Robeson A, Huang B, Zhang L, et al. Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Oncogene. 2015;34:3264-72 pubmed 出版商
  • 免疫印迹; 小鼠
Sandow J, Dorstyn L, O Reilly L, Tailler M, Kumar S, Strasser A, et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ. 2014;21:475-80 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Tinnikov A, Samuels H. A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli. PLoS ONE. 2013;8:e61085 pubmed 出版商
  • 免疫印迹; 人类
Inoue S, Browne G, Melino G, Cohen G. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ. 2009;16:1053-61 pubmed 出版商
Pham D, Do H, Bruelle C, Kukkonen J, Eriksson O, Mogollón I, et al. p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3. J Biol Chem. 2016;291:10747-58 pubmed 出版商
Garcia Belinchón M, Sánchez Osuna M, Martínez Escardó L, Granados Colomina C, Pascual Guiral S, Iglesias Guimarais V, et al. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death. J Biol Chem. 2015;290:20841-55 pubmed 出版商
Venkatesh A, Ma S, Le Y, Hall M, Rüegg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed 出版商
Manzl C, Fava L, Krumschnabel G, Peintner L, Tanzer M, Soratroi C, et al. Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell Death Dis. 2013;4:e942 pubmed 出版商
Delgado M, Olsson M, Lincoln F, Zhivotovsky B, Rehm M. Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution. Biochim Biophys Acta. 2013;1833:2279-92 pubmed 出版商
Happo L, Cragg M, Phipson B, Haga J, Jansen E, Herold M, et al. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood. 2010;116:5256-67 pubmed 出版商
Villapol S, Bonnin P, Fau S, Baud O, Renolleau S, Charriaut Marlangue C. Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Am J Pathol. 2009;175:2111-20 pubmed 出版商
Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, et al. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009;185:291-303 pubmed 出版商
Camacho I, Singh N, Hegde V, Nagarkatti M, Nagarkatti P. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol. 2005;175:90-103 pubmed
Yakovlev A, Di Giovanni S, Wang G, Liu W, Stoica B, Faden A. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74 pubmed
Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004;304:843-6 pubmed
Read S, Baliga B, Ekert P, Vaux D, Kumar S. A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol. 2002;159:739-45 pubmed
产品信息
产品编号 :
ALX-804-356
目录代码 :
ALX-804-356-C100
产品名称 :
胱氨酸-天冬氨酸蛋白酶2单克隆抗体(11B4)
宿主物种 :
大鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
Pubmed号列表 :
24309929, 23747563, 23596516, 20829369, 19815715, 19325570, 15972635, 15102863, 15073321, 12460989
克隆 :
11B4
抗体亚型 :
IgG2a
物种活性 :
Human, Mouse, Rat, Monkey, Dog
免疫原 :
Recombinant human caspase-2 p19 fragment.
特异性 :
Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.
缓冲液 :
液体。 在PBS含0.02% 叠氮化钠
用途 :
Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot. For FC, ICC and IHC (FS) use MAb to Caspase-2 (10C6) (Prod. No. ALX-804-355).
应用摘要 :
免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。