产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
c-erbB-2 (human) monoclonal antibody (MGR2)
目录 :
ALX-804-573-C100
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
MGR2
反应物种 :
人类
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 图 2b
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed 出版商
Leoni V, Gatta V, Palladini A, Nicoletti G, Ranieri D, Dall Ora M, et al. Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases. Oncotarget. 2015;6:34774-87 pubmed 出版商
Tamborini E, Virdis E, Negri T, Orsenigo M, Brich S, Conca E, et al. Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas. Neuro Oncol. 2010;12:776-89 pubmed 出版商
Magnifico A, Albano L, Campaner S, Delia D, Castiglioni F, Gasparini P, et al. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin Cancer Res. 2009;15:2010-21 pubmed 出版商
Pupa S, Iezzi M, Di Carlo E, Invernizzi A, Cavallo F, Meazza R, et al. Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination. Cancer Res. 2005;65:1071-8 pubmed
Orlandi R, Menard S, Colnaghi M, Boyer C, Felici F. Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides. Eur J Immunol. 1994;24:2868-73 pubmed
Tagliabue E, Centis F, Campiglio M, Mastroianni A, Martignone S, Pellegrini R, et al. Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification. Int J Cancer. 1991;47:933-7 pubmed
Centis F, Tagliabue E, Uppugunduri S, Pellegrini R, Martignone S, Mastroianni A, et al. p185 HER2/neu epitope mapping with murine monoclonal antibodies. Hybridoma. 1992;11:267-76 pubmed
产品信息
产品编号 :
ALX-804-573
目录代码 :
ALX-804-573-C100
产品名称 :
c-erbB-2 (human) monoclonal antibody (MGR2)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
Pubmed号列表 :
20164240, 19276287, 15705909, 7525309, 1672668, 1379973
克隆 :
MGR2
抗体亚型 :
IgG1
物种活性 :
人类
背景 :
The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.
别名 :
ErbB2, HER-2, neu
免疫原 :
CaLu 3 lung carcinoma cell line.
特异性 :
Recognizes an epitope present in the extracellular domain of c-erbB-2 (HER-2; neu).
缓冲液 :
液体。 在150mM氯化钠, pH值7.4, 含0.02% 叠氮化钠
用途 :
Immunoprecipitation: Detects a band of ~185kDa.
应用摘要 :
FC, 免疫组化(FS), 免疫沉淀
储存 :
+4°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。