Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

c-Myc(人类)单克隆抗体(6A10)

ALX-804-632-L001

1毫升

单克隆

大鼠

未共轭

6A10

免疫印迹, 免疫细胞化学, 免疫沉淀

ALX-804-632-L001

c-Myc(人类)单克隆抗体(6A10)

大鼠

单克隆

抗体

1毫升

15674325, 10744730, 9506959

6A10

IgG2a

人类

Myc proteins are important regulators of cell behaviour and work as transcription factors that belong to the basic region/helix-loop-helix/leucine zipper family of DNA binding proteins. To regulate its target genes, Myc recruits several different cofactors (e.g. PARP-10). They control a variety of cellular functions including protein synthesis, cell cycle progression, and apoptosis, thereby modulating cell growth and proliferation, differentiation, and survivial of cells. The family of myc genes includes B-myc, L-myc, N-myc and s-myc; however only c-myc, L-myc and N-myc have neoplastic potential. The c-Myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene. It is a proto-oncogene, whereas the deregulated expression of c-Myc is observed in the majority of human and animal tumors often with poor prognosis. The proto-oncogene c-Myc is implicated in various physiological processes; cell growth, proliferation, loss of differentiation and cell death (apoptosis). It also has been implicated in the loss and dysfunction of insulin-producing beta cells in diabetes. Studies in mice suggest that c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells. c-Myc activity is normally tightly controlled by external signals including growth factors, mitogens and β-catenin which promote, and factors as TGF-beta which inhibit.

Myc原癌基因, 转录因子p64

人类c Myc(氨基酸1-262)

Liquid. Tissue culture supernatant (TCS) containing 0.1% sodium azide.

免疫细胞化学, 免疫沉淀, 免疫印迹

+4°C