产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
NLRP3/NALP3(人类)单克隆抗体(Nalpy3-b)
目录 :
ALX-804-819-C100
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Nalpy3-b
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 5a
Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Choulaki C, Papadaki G, Repa A, Kampouraki E, Kambas K, Ritis K, et al. Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis. Arthritis Res Ther. 2015;17:257 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Tseng W, Thein T, Kinnunen K, Lashkari K, Gregory M, D Amore P, et al. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013;54:110-20 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
de Koning H, Rodijk Olthuis D, van Vlijmen Willems I, Joosten L, Netea M, Schalkwijk J, et al. A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis. J Invest Dermatol. 2010;130:2611-20 pubmed 出版商
  • 免疫印迹; 人类
Mayor A, Martinon F, De Smedt T, Petrilli V, Tschopp J. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 2007;8:497-503 pubmed
Wu Y, Lai M. Measuring NLR Oligomerization V: In Situ Proximity Ligation Assay. Methods Mol Biol. 2016;1417:185-95 pubmed 出版商
Repa A, Bertsias G, Petraki E, Choulaki C, Vassou D, Kambas K, et al. Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever. Hum Immunol. 2015;76:488-95 pubmed 出版商
McGilligan V, Gregory Ksander M, Li D, Moore J, Hodges R, Gilmore M, et al. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS ONE. 2013;8:e74010 pubmed 出版商
Benoit M, Clarke E, Morgado P, Fraser D, Tenner A. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 2012;188:5682-93 pubmed 出版商
Shio M, Tiemi Shio M, Eisenbarth S, Savaria M, Vinet A, Bellemare M, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009;5:e1000559 pubmed 出版商
Lev Sagie A, Prus D, Linhares I, Lavy Y, Ledger W, Witkin S. Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol. 2009;200:303.e1-6 pubmed 出版商
Kummer J, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem. 2007;55:443-52 pubmed
Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed
产品信息
产品编号 :
ALX-804-819
目录代码 :
ALX-804-819-C100
产品名称 :
NLRP3/NALP3(人类)单克隆抗体(Nalpy3-b)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
100微克
Pubmed号列表 :
26642243, 26074413, 24040145, 23221073, 22523386, 19696895, 19254587, 17164409, 15030775
克隆 :
Nalpy3-b
抗体亚型 :
IgG1
物种活性 :
人类
别名 :
NACHT-, LRR- and PYD-containing protein 3, CIAS1, Cryopyrin, Cold autoinflammatory syndrome 1 protein, PYPAF1, PYRIN-containing APAF1-like protein 1
免疫原 :
Recombinant human NLRP3/NALP3 (NACHT-, LRR- and PYD-containing protein 3) (pyrin domain).
特异性 :
Detects endogenous protein by IP and WB.
缓冲液 :
液体。 在PBS含0.02% 叠氮化钠
应用摘要 :
免疫组化(FS), 免疫沉淀, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。