Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

TIRAP (human) monoclonal antibody (Sebi-1)

ALX-804-829-C100

100微克

单克隆

大鼠

未共轭

Sebi-1

免疫印迹, 免疫沉淀

ALX-804-829-C100

TIRAP (human) monoclonal antibody (Sebi-1)

大鼠

单克隆

抗体

100微克

Sebi-1

IgG2a

人类

Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading pathogens. Recognition of microbial components by TLRs triggers activation of the innate immune system. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Trif (TIR-domain-containing adaptor inducing interferon-β), TIRAP (TIR domain-containing adaptor protein)/Mal (MyD88 adaptor-like), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). MyD88 is common to all TLR-mediated pathways, which lead to the production of inflammatory cytokines, whereas TRIF mediates induction of IFN-β in TLR3 and TLR4 signalling pathways. TIRAP/Mal is implicated in the TLR2- and TLR4-mediated MyD88-dependent signalling pathway. TRAM is specifically involved in the TLR4-mediated TRIF-dependent pathway. Thus, TIR domain-containing adaptors provide specificity of TLR signalling.

Toll-interleukin 1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Mal

Recombinant human TIRAP (Mal) (aa 1-215).

液体。 在PBS含0.02% 叠氮化钠

免疫沉淀, 免疫印迹

-20°C