产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Bufalin
目录 :
BML-AP303-0010
规格 :
10毫克
更多信息或购买 :
文章摘录数: 10
参考文献
Akimova O, Bagrov A, Lopina O, Kamernitsky A, Tremblay J, Hamet P, et al. Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells. J Biol Chem. 2005;280:832-9 pubmed
Wang Z, Wen J, Zhang J, Ye M, Guo D. Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography. Biomed Chromatogr. 2004;18:318-22 pubmed
Terness P, Navolan D, Dufter C, Kopp B, Opelz G. The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity. Int Immunopharmacol. 2001;1:119-34 pubmed
McGowan M, Russell P, Carper D, Lichtstein D. Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. J Pharmacol Exp Ther. 1999;289:1559-63 pubmed
Kawazoe N, Watabe M, Masuda Y, Nakajo S, Nakaya K. Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene. 1999;18:2413-21 pubmed
Dasgupta A, Emerson L. Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations. Life Sci. 1998;63:781-8 pubmed
Yamada K, Hino K, Tomoyasu S, Honma Y, Tsuruoka N. Enhancement by bufalin of retinoic acid-induced differentiation of acute promyelocytic leukemia cells in primary culture. Leuk Res. 1998;22:589-95 pubmed
Krenn L, Kopp B. Bufadienolides from animal and plant sources. Phytochemistry. 1998;48:1-29 pubmed
Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K. Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Oncogene. 1998;16:779-87 pubmed
Brownlee A, Johnson P, Mills I. Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes. Clin Sci (Lond). 1990;78:169-74 pubmed
产品信息
产品编号 :
BML-AP303
目录代码 :
BML-AP303-0010
产品名称 :
Bufalin
产品类型 :
Biochemical
规格 :
10毫克
Pubmed号列表 :
15494417, 15236440, 11367509, 10336553, 10229192, 9740315, 9680108, 9621450, 9488042, 2155744
产品描述 :
Cardiotonic steroid specific Na+/K+-ATPase inhibitor. More potent than ouabain (Prod. No. BML-CM109). Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein.
别名 :
(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide, 5β,20(22)-Bufadienolide-3β,14-diol
纯度 :
≥97%(HPLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。