产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Calmidazolium chloride
目录 :
BML-CA300-0050
规格 :
50毫克
更多信息或购买 :
文章摘录数: 10
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Nachmany A, Gold V, Tsur A, Arad D, Weil M. Neural tube closure depends on nitric oxide synthase activity. J Neurochem. 2006;96:247-53 pubmed
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Dedkova E, Ji X, Lipsius S, Blatter L. Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2004;286:C406-15 pubmed
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Lacza Z, Puskar M, Figueroa J, Zhang J, Rajapakse N, Busija D. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic Biol Med. 2001;31:1609-15 pubmed
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Schaefer A, Magocsi M, Stocker U, Fandrich A, Marquardt H. Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin. J Biol Chem. 1996;271:13484-90 pubmed
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Wright L, Bertics P, Siegel F. Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors. J Biol Chem. 1996;271:12737-43 pubmed
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Hu J, El Fakahany E. The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells. Neuroreport. 1993;4:198-200 pubmed
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Murthy K, Makhlouf G. Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2. J Biol Chem. 1994;269:15977-80 pubmed
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Gietzen K, Sadorf I, Bader H. A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors. Biochem J. 1982;207:541-8 pubmed
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Asano M. Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tr. J Pharmacol Exp Ther. 1989;251:764-73 pubmed
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Schini V, Vanhoutte P. Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta. J Pharmacol Exp Ther. 1992;261:553-9 pubmed
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产品信息
产品编号 :
BML-CA300
目录代码 :
BML-CA300-0050
产品名称 :
Calmidazolium chloride
产品类型 :
Biochemical
规格 :
50毫克
Pubmed号列表 :
16300634, 14512291, 11744335, 8662717, 8662690, 8384025, 7515875, 6299272, 2810127, 1374468
产品描述 :
Binds reversibly to calmodulin, inhibiting calmodulin-mediated enzyme activation. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=1 µM). Cell permeable. Inhibits calmodulin N-methyltransferase (Ki=65 nM). Blocks Ca2+-calmodulin binding to NOS. Inhibitor of voltage-gated Ca2+ channels
别名 :
R24571
纯度 :
≥98%(HPLC)
储存 :
+4°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。