产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Diphenyleneiodonium chloride
目录 :
BML-CN240-0010
规格 :
10毫克
更多信息或购买 :
文章摘录数: 10
参考文献
Scaife R. Selective and irreversible cell cycle inhibition by diphenyleneiodonium. Mol Cancer Ther. 2005;4:876-84 pubmed
Balcerczyk A, Soszyński M, Rybaczek D, Przygodzki T, Karowicz Bilinska A, Maszewski J, et al. Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. Biochem Pharmacol. 2005;69:1263-73 pubmed
Scaife R. G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium. Mol Cancer Ther. 2004;3:1229-37 pubmed
Morre D. Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor. Antioxid Redox Signal. 2002;4:207-12 pubmed
Mendes A, Carvalho A, Caramona M, Lopes M. Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species. Mediators Inflamm. 2001;10:209-15 pubmed
Kono H, Rusyn I, Uesugi T, Yamashina S, Connor H, Dikalova A, et al. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1005-12 pubmed
Tew D. Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry. 1993;32:10209-15 pubmed
Cross A, Jones O. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J. 1986;237:111-6 pubmed
Hancock J, Jones O. The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. Biochem J. 1987;242:103-7 pubmed
Acker H, Dufau E, Huber J, Sylvester D. Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body. FEBS Lett. 1989;256:75-8 pubmed
产品信息
产品编号 :
BML-CN240
目录代码 :
BML-CN240-0010
产品名称 :
Diphenyleneiodonium chloride
产品类型 :
Biochemical
规格 :
10毫克
Pubmed号列表 :
15956245, 15794948, 15486190, 11970854, 11577997, 11292610, 8399148, 3800872, 3036079, 2806553
产品描述 :
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has been shown to be irreversibly inhibited by this compound in cultured peritoneal macrophages (IC50=30nM).
别名 :
DPI chloride, Dibenziodolium chloride
纯度 :
≥98%(HPLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。