产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
BAY 11-7085
目录 :
BML-EI279-0010
规格 :
10毫克
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 6
参考文献
Lee K, Jeong J, Kim S, Cho S, Kolliputi N, Ko Y, et al. Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax. 2016;71:52-63 pubmed 出版商
Fang W, Mafuvadze B, Yao M, Zou A, Portsche M, Cheng N. TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms. PLoS ONE. 2015;10:e0135063 pubmed 出版商
Robe P, Bentires Alj M, Bonif M, Rogister B, Deprez M, Haddada H, et al. In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas. Clin Cancer Res. 2004;10:5595-603 pubmed
Petegnief V, Saura J, de Gregorio Rocasolano N, Paul S. Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E. Neuroscience. 2001;104:223-34 pubmed
Koedel U, Bayerlein I, Paul R, Sporer B, Pfister H. Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis. J Infect Dis. 2000;182:1437-45 pubmed
Pierce J, Schoenleber R, Jesmok G, Best J, Moore S, Collins T, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997;272:21096-103 pubmed
产品信息
产品编号 :
BML-EI279
目录代码 :
BML-EI279-0010
产品名称 :
BAY 11-7085
产品类型 :
Biochemical
规格 :
10毫克
Pubmed号列表 :
26543090, 26252654, 15328202, 11311545, 11023466, 9261113
产品描述 :
An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.
纯度 :
≥99%(TLC)
储存 :
Ambient
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。