产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
GM-6001
目录 :
BML-EI300-0001
规格 :
1毫克
价格 :
67美元
更多信息或购买 :
文章摘录数: 10
参考文献
Nan L, Wei J, Jacko A, Culley M, Zhao J, Natarajan V, et al. Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration. Biochim Biophys Acta. 2016;1863:229-35 pubmed 出版商
Gioia M, Vindigni G, Testa B, Raniolo S, Fasciglione G, Coletta M, et al. Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells. PLoS ONE. 2015;10:e0141270 pubmed 出版商
Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, et al. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med. 2015;21:1048-53 pubmed 出版商
Hartmann M, Parra L, Ruschel A, Lindner C, Morrison H, Herrlich A, et al. Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization. J Biol Chem. 2015;290:17041-54 pubmed 出版商
Moss M, Rasmussen F. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal Biochem. 2007;366:144-8 pubmed
Kang T, Tschesche H, Amy Sang Q. Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19. Exp Cell Res. 2004;298:285-95 pubmed
Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt B. Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A. 2004;101:10000-5 pubmed
Turk B, Wong T, Schwarzenbacher R, Jarrell E, Leppla S, Collier R, et al. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol. 2004;11:60-6 pubmed 出版商
Ma D, Wu W, Yang G, Li J, Li J, Ye Q. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2004;14:47-50 pubmed
Park H, Jin Y, Hurst D, Monroe C, Lee S, Schwartz M, et al. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem. 2003;278:51646-53 pubmed
产品信息
产品编号 :
BML-EI300
目录代码 :
BML-EI300-0001
产品名称 :
GM-6001
产品类型 :
Biochemical
规格 :
1毫克
标价(美元) :
67美元
Pubmed号列表 :
26597701, 26495844, 26259032, 25925953, 17548045, 15242783, 15220480, 14718924, 14684295, 14532275
产品描述 :
Potent broad-spectrum hydroxamate inhibitor of matrix metalloproteinases (MMPs). Ki values have been reported for the following human MMPs: MMP-1 (fibroblast collagenase): 0.4nM; MMP-2 (gelatinase A): 0.5nM; MMP-3 (stromelysin-1): 27nM; MMP-7 (matrilysin): 3.7nM; MMP-8 (neutrophil collagenase): 0.1nM; MMP-9 (gelatinase B): 0.2nM; MMP-12 (metalloelastase): 3.6nM; MMP-14 (MT1-MMP): 13.4nM; MMP-26 (endometase): 0.36nM. Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE, ADAM19, other ADAMs, anthrax lethal factor, neprilysin, leucine aminopeptidase, and DPPIII. Typical concentration range for use in tissue culture is 10-25µM. This inhibitor has also been used in vivo.
别名 :
Galardin, Ilomastat, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
纯度 :
≥98%(HPLC)
缓冲液 :
Lyophilized solid.
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。