产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
GM-6001
目录 :
BML-EI300-0005
规格 :
5毫克
更多信息或购买 :
文章摘录数: 10
参考文献 |
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Moss M, Rasmussen F. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal Biochem. 2007;366:144-8 pubmed
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Kang T, Tschesche H, Amy Sang Q. Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19. Exp Cell Res. 2004;298:285-95 pubmed
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Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt B. Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A. 2004;101:10000-5 pubmed
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Ma D, Wu W, Yang G, Li J, Li J, Ye Q. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2004;14:47-50 pubmed
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Park H, Jin Y, Hurst D, Monroe C, Lee S, Schwartz M, et al. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem. 2003;278:51646-53 pubmed
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产品信息
产品编号 :
BML-EI300
目录代码 :
BML-EI300-0005
产品名称 :
GM-6001
产品类型 :
Biochemical
规格 :
5毫克
Pubmed号列表 :
26597701, 26495844, 26259032, 25925953, 17548045, 15242783, 15220480, 14718924, 14684295, 14532275
产品描述 :
Potent broad-spectrum hydroxamate inhibitor of matrix metalloproteinases (MMPs). Ki values have been reported for the following human MMPs: MMP-1 (fibroblast collagenase): 0.4nM; MMP-2 (gelatinase A): 0.5nM; MMP-3 (stromelysin-1): 27nM; MMP-7 (matrilysin): 3.7nM; MMP-8 (neutrophil collagenase): 0.1nM; MMP-9 (gelatinase B): 0.2nM; MMP-12 (metalloelastase): 3.6nM; MMP-14 (MT1-MMP): 13.4nM; MMP-26 (endometase): 0.36nM. Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE, ADAM19, other ADAMs, anthrax lethal factor, neprilysin, leucine aminopeptidase, and DPPIII. Typical concentration range for use in tissue culture is 10-25µM. This inhibitor has also been used in vivo.
别名 :
Galardin, Ilomastat, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
纯度 :
≥98%(HPLC)
缓冲液 :
Lyophilized solid.
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。