产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Kenpaullone
目录 :
BML-EI310-0005
规格 :
5毫克
更多信息或购买 :
文章摘录数: 10
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Bain J, McLauchlan H, Elliott M, Cohen P. The specificities of protein kinase inhibitors: an update. Biochem J. 2003;371:199-204 pubmed
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Leclerc S, Garnier M, Hoessel R, Marko D, Bibb J, Snyder G, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?. J Biol Chem. 2001;276:251-60 pubmed
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Leost M, Schultz C, Link A, Wu Y, Biernat J, Mandelkow E, et al. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem. 2000;267:5983-94 pubmed
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Sausville E, Johnson J, Alley M, Zaharevitz D, Senderowicz A. Inhibition of CDKs as a therapeutic modality. Ann N Y Acad Sci. 2000;910:207-21; discussion 221-2 pubmed
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Gussio R, Zaharevitz D, McGrath C, Pattabiraman N, Kellogg G, Schultz C, et al. Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition. Anticancer Drug Des. 2000;15:53-66 pubmed
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Kunick C, Schultz C, Lemcke T, Zaharevitz D, Gussio R, Jalluri R, et al. 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity. Bioorg Med Chem Lett. 2000;10:567-9 pubmed
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Gray N, Detivaud L, Doerig C, Meijer L. ATP-site directed inhibitors of cyclin-dependent kinases. Curr Med Chem. 1999;6:859-75 pubmed
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Schultz C, Link A, Leost M, Zaharevitz D, Gussio R, Sausville E, et al. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem. 1999;42:2909-19 pubmed
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Zaharevitz D, Gussio R, Leost M, Senderowicz A, Lahusen T, Kunick C, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999;59:2566-9 pubmed
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Kunick C. Fused azepinones with antitumor activity. Curr Pharm Des. 1999;5:181-94 pubmed
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产品信息
产品编号 :
BML-EI310
目录代码 :
BML-EI310-0005
产品名称 :
Kenpaullone
产品类型 :
Biochemical
规格 :
5毫克
Pubmed号列表 :
12534346, 11013232, 10998059, 10911915, 10888036, 10741555, 10495356, 10425100, 10363974, 10066889
产品描述 :
Potent inhibitor of CDK1/cyclin B (IC50=400nM). Also inhibits CDK2/cyclin A (IC50=680nM) , CDK5 (IC50=850nM) and with much less effect other kinases. More recently, kenpaullone has been found to be a useful GSK-3β inhibitor (IC50=23nM). Induces pluripotency in somatic cells when used in combination with reprogramming factors. Increases neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.
别名 :
9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
纯度 :
≥98%(TLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。