产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
芹菜素
目录 :
BML-EI345-0100
规格 :
100毫克
更多信息或购买 :
文章摘录数: 10
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Nicholas C, Batra S, Vargo M, Voss O, Gavrilin M, Wewers M, et al. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol. 2007;179:7121-7 pubmed
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Shukla S, Gupta S. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle. 2007;6:1102-14 pubmed
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Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. 2007;30:233-45 pubmed
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Fang J, Zhou Q, Liu L, Xia C, Hu X, Shi X, et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis. 2007;28:858-64 pubmed
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Yamada M, Katsuma S, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci U S A. 2005;102:7736-41 pubmed
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Torkin R, Lavoie J, Kaplan D, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 2005;4:1-11 pubmed
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Shen J, Channavajhala P, Seldin D, Sonenshein G. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol. 2001;167:4919-25 pubmed
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Song D, Sussman D, Seldin D. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. J Biol Chem. 2000;275:23790-7 pubmed
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Trochon V, Blot E, Cymbalista F, Engelmann C, Tang R, Thomaidis A, et al. Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. Int J Cancer. 2000;85:691-6 pubmed
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产品信息
产品编号 :
BML-EI345
目录代码 :
BML-EI345-0100
产品名称 :
芹菜素
产品类型 :
Biochemical
规格 :
100毫克
Pubmed号列表 :
19427869, 17982104, 17457054, 17143534, 17071632, 15897466, 15657348, 11673497, 10806215, 10699950
产品描述 :
Apigenin is an antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. Is a MAP-Kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. Induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels. Apigenin is a selective inhibitor of CK2. In WEHI 231 cells inhibition of CK2 by apigenin decreased the rate of IκBα turnover and nuclear levels of NF-κB (20 µM). It blocks proliferation of Wnt-1 transfected cells and abrogates phosphorylation of β-catenin. In a rat model of glomerulonephritis, inhibition of CK2 by apigenin ameliorates renal dysfunction.
纯度 :
≥97%(HPLC)
储存 :
Ambient
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。