Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

p53(人类),(重组)(谷胱甘肽S-转移酶标签)

BML-FW9370-0050

50微克

BML-FW9370-0050

p53(人类),(重组)(谷胱甘肽S-转移酶标签)

蛋白

50微克

p53 is a much studied and complex multifunctional protein, which acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction appears to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications. Such modification results in the activation of p53 protein as a transcription factor that initiates a program of cell cycle arrest, cellular senescence or apoptosis.

TRP53, 肿瘤蛋白p53

≥90%(十二烷基磺酸钠-PAGE)

液体。 在50mM钠磷酸盐, pH值7.5, 含50mM氯化钠

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

-80°C