产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
放线菌素D
目录 :
BML-GR300-0005
规格 :
5毫克
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 10
参考文献
He T, Hatem E, Vernis L, Lei M, Huang M. PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. J Exp Clin Cancer Res. 2015;34:152 pubmed 出版商
Pfister A, Keil M, Kühl M. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem. 2015;290:10905-18 pubmed 出版商
Wang M, Liu S, Liu Y, Zheng D. Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells. Neurosci Res. 2007;59:40-6 pubmed
Kalousek I, Brodska B, Otevrelova P, Roselova P. Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007;18:763-72 pubmed
Mischo H, Hemmerich P, Grosse F, Zhang S. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J Biol Chem. 2005;280:9586-94 pubmed
Qing C, Miao Z, Tong L, Zhang J, Ding J. Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity. Acta Pharmacol Sin. 2003;24:415-21 pubmed
Kleeff J, Kornmann M, Sawhney H, Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer. 2000;86:399-407 pubmed
Akahori M, Yamada S, Takeyama N, Tanaka T. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice. J Surg Res. 1999;85:286-93 pubmed
Bailey S, Graves D, Rill R, Marsch G. Influence of DNA base sequence on the binding energetics of actinomycin D. Biochemistry. 1993;32:5881-7 pubmed
Verhaegen S, McGowan A, Brophy A, Fernandes R, Cotter T. Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line. Biochem Pharmacol. 1995;50:1021-9 pubmed
产品信息
产品编号 :
BML-GR300
目录代码 :
BML-GR300-0005
产品名称 :
放线菌素D
产品类型 :
Biochemical
规格 :
5毫克
Pubmed号列表 :
26689287, 25759387, 17707539, 17581298, 15613478, 12740176, 10760829, 10423331, 8504108, 7575657
产品描述 :
An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10µg/ml in cell culture for haltiong transcription. The product is not sterile.
纯度 :
≥98%(TLC)
储存 :
-20°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。