产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
Pifithrin-α
目录 :
BML-GR325-0025
规格 :
25毫克
更多信息或购买 :
文章摘录数: 8
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Murphy P, Galigniana M, Morishima Y, Harrell J, Kwok R, Ljungman M, et al. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem. 2004;279:30195-201 pubmed
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Muller F, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, et al. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ. 2004;11:485-93 pubmed
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Javelaud D, Besancon F. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J Biol Chem. 2002;277:37949-54 pubmed
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Alves da Costa C, Paitel E, Mattson M, Amson R, Telerman A, Ancolio K, et al. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc Natl Acad Sci U S A. 2002;99:4043-8 pubmed
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Lakkaraju A, Dubinsky J, Low W, Rahman Y. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem. 2001;276:32000-7 pubmed
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Komarova E, Gudkov A. Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry (Mosc). 2000;65:41-8 pubmed
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Ferber D. Cancer research. A new way to combat therapy side effects. Science. 1999;285:1651, 1653 pubmed
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Komarov P, Komarova E, Kondratov R, Christov Tselkov K, Coon J, Chernov M, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 1999;285:1733-7 pubmed
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产品信息
产品编号 :
BML-GR325
目录代码 :
BML-GR325-0025
产品名称 :
Pifithrin-α
产品类型 :
Biochemical
规格 :
25毫克
Pubmed号列表 :
15145929, 14752511, 12151395, 11904448, 11406618, 10702639, 10523177, 10481009
产品描述 :
Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.
别名 :
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, PFT-α
纯度 :
≥98%(TLC)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。