产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
PARP-1单克隆抗体(C-2-10)
目录 :
BML-SA250-0050
规格 :
50微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C-2-10
反应物种 :
人类, 小鼠, 大鼠, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 6
Koyani C, Kitz K, Rossmann C, Bernhart E, Huber E, Trummer C, et al. Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochem Pharmacol. 2016;104:29-41 pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 1a
Rasmussen R, Gajjar M, Jensen K, Hamerlik P. Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma. Mol Oncol. 2016;10:751-63 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Liberante F, Pouryahya T, McMullin M, Zhang S, Mills K. Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget. 2016;7:6609-19 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Charni M, Molchadsky A, Goldstein I, Solomon H, Tal P, Goldfinger N, et al. Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. Cell Death Differ. 2016;23:509-20 pubmed 出版商
  • 免疫印迹; 人类
Majuelos Melguizo J, Rodríguez M, López Jiménez L, Rodríguez Vargas J, Martí Martín Consuegra J, Serrano Sáenz S, et al. PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma. Oncotarget. 2015;6:4790-803 pubmed
  • 免疫印迹; 人类; 图 3
Geserick P, Wang J, Feoktistova M, Leverkus M. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death Dis. 2014;5:e1412 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类; 图 3
Resch U, Cuapio A, Sturtzel C, Hofer E, de Martin R, Holper Schichl Y. Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem. 2014;289:25088-100 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Gastaldello S, Chen X, Callegari S, Masucci M. Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells. PLoS Pathog. 2013;9:e1003664 pubmed 出版商
  • 免疫印迹; 人类
Sémiramoth N, Gleizes A, Turbica I, Sandré C, Marin Esteban V, Gorges R, et al. Afa/Dr-expressing, diffusely adhering Escherichia coli strain C1845 triggers F1845 fimbria-dependent phosphatidylserine externalization on neutrophil-like differentiated PLB-985 cells through an apoptosis-independent mechanism. Infect Immun. 2010;78:2974-83 pubmed 出版商
  • 免疫印迹; 人类
Koschny R, Holland H, Sykora J, Erdal H, Krupp W, Bauer M, et al. Bortezomib sensitizes primary human esthesioneuroblastoma cells to TRAIL-induced apoptosis. J Neurooncol. 2010;97:171-85 pubmed 出版商
  • 免疫印迹; 人类
Rossi M, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, et al. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity. J Biol Chem. 2009;284:31616-24 pubmed 出版商
  • 免疫印迹; 人类
Koschny R, Ganten T, Sykora J, Haas T, Sprick M, Kolb A, et al. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology. 2007;45:649-58 pubmed
  • 免疫印迹; 猕猴
Martin Latil S, Mousson L, Autret A, Colbere Garapin F, Blondel B. Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. J Virol. 2007;81:4457-64 pubmed
Zelensky A, Schimmel J, Kool H, Kanaar R, Tijsterman M. Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA. Nat Commun. 2017;8:66 pubmed 出版商
Collins T, Ylanko J, Geng F, Andrews D. A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis. Assay Drug Dev Technol. 2015;13:547-57 pubmed 出版商
Ciccarone F, Valentini E, Zampieri M, Caiafa P. 5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme. Oncotarget. 2015;6:24333-47 pubmed
Knorr K, Schneider P, Meng X, Dai H, Smith B, Hess A, et al. MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors. Cell Death Differ. 2015;22:2133-42 pubmed 出版商
Xu H, Cho S, Bang M, Bae C, Choi Y, Li Y, et al. FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol. 2015;46:2309-16 pubmed 出版商
Greenhough A, Wallam C, Hicks D, Moorghen M, Williams A, Paraskeva C. The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. Oncogene. 2010;29:3398-410 pubmed 出版商
Schmidt M, Hupe M, Endres N, Raghavan B, Kavuri S, Geserick P, et al. The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis. J Cell Mol Med. 2010;14:1760-76 pubmed 出版商
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol. 2002;157:455-68 pubmed
产品信息
产品编号 :
BML-SA250
目录代码 :
BML-SA250-0050
产品名称 :
PARP-1单克隆抗体(C-2-10)
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
抗体
规格 :
50微升
Pubmed号列表 :
26358154, 25823424
克隆 :
C-2-10
抗体亚型 :
IgG1
物种活性 :
Human, Mouse, Rat, Monkey, Hamster, Bovine
别名 :
Poly(ADP-ribose) polymerase-1
免疫原 :
Purified calf thymus poly(ADP-ribose) polymerase (PARP).
特异性 :
Recognizes an epitope in the C-terminal part of the DNA binding domain of PARP.
缓冲液 :
液体。 小鼠腹水含0.02% 叠氮化钠
用途 :
Detects bands ~116kDa (intact PARP) and ~85kDa (apoptosis-induced cleavage fragment) by Western blot.
应用摘要 :
酶联免疫吸附测定, 免疫组化, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。