Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

α-Synuclein polyclonal antibody

BML-SA3400-0025

25微升

多克隆

domestic rabbit

未共轭

人类, 大鼠

免疫印迹, 免疫组化

BML-SA3400-0025

α-Synuclein polyclonal antibody

兔

多克隆

抗体

25微升

25609609

人类, 大鼠

α-Synuclein accumulates in Lewy bodies, which are intraneuronal cytoplasmic inclusions present in the brains of sporadic Parkinson's disease patients, and is implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. α-Synuclein appears to associate with other proteins that aggregate and is found in β-amyloid plaques and neuritic tangles in Alzheimer's disease.

NACP, Non-A β component of senile plaques

Synthetic peptide corresponding to [Cys] + aa 117-131 of human α-synuclein conjugated to KLH. The sequence is conserved in rat α-synuclein except for two substitutions, namely Asp121Ser and Asn122Ser.

This antibody has been shown to react strongly with human brain-derived α-synuclein. The antibody also reacts with rat brain-derived α-synuclein but reactivity appears substantially less than with human.

液体。 在PBS, pH值7.4, 含10mM叠氮化钠

Western blot: The antibody has been characterized by single dimension SDS-PAGE using recombinant α- and β-synucleins as well as rat, mouse and human brain lysates with and without peptide blockade. Studies with the recombinant proteins demonstrated the absolute specificity of the antibody for α-synuclein. The antibody gives a strong band at a relative molecular weight of approximately 15kDa with human brain lysate which is wholly abolished by preincubation with the immunizing peptide (Prod. No. BML-SP9340). Immunohistochemistry: The antibody has been tested on de-waxed tissue sections of human brain fixed in neutral buffered formaldehyde. A standard protocol should be followed.

免疫组化, 免疫印迹

-20°C