产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
抗体
产品名称 :
蛋白酶激活受体(细胞外)(人类)多克隆抗体
目录 :
BML-SA650-0200
规格 :
200微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
产品信息
产品编号 :
BML-SA650
目录代码 :
BML-SA650-0200
产品名称 :
蛋白酶激活受体(细胞外)(人类)多克隆抗体
宿主物种 :
克隆性 :
多克隆
产品类型 :
抗体
规格 :
200微升
物种活性 :
人类
背景 :
PAR-1 belongs to a four member family of G protein-coupled receptors (PAR-1 to -4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways1-3 Different PARs are activated by different proteinases. Hence, PAR-1 is activated by thrombin (and is also known as the thrombin receptor), as are PAR-3 and PAR-4, while PAR-2 is activated by trypsin1-3 PAR-1 can be also cleaved and activated by other proteinases such as plasmin, Factor Xa, and cathepsin G PAR-1 signals through several G proteins including Gαq, Gαi, and Gα12/13, resulting in the activation of several transduction pathways including Ca2+ mobilization, Rho and Rac signaling, and MAPK activation1-3 PAR-1 is expressed in several cell types including platelets, leukocytes, vascular endothelial cells, gastrointestinal epithelial cells, myocytes, and neurons. The best studied physiological function of PAR-1 is its involvement in the coagulation cascade. Thrombin activates the receptor on the surface of platelets inducing platelet aggregation, granular secretion, and procoagulant activity. PAR-1 also plays a role in vascular ontogenesis. PAR-1 also plays important roles in tumor growth and metastasis. PAR-1 is upregulated in several human cancers as are several proteinases such as plasmin and matrix metalloproteases that act as PAR-1 ligands, thereby creating an autocrine loop. PAR-1 activation in cancer cells transmits mitogenic signals through the activation of the erk1/2 pathway and is involved in tumor spread via its pro-angiogenic activity.4
别名 :
PAR-1
免疫原 :
合成多肽对应于氨基酸61-76人的PAR-1(蛋白酶激活受体)
缓冲液 :
冻干。 在PBS, pH值7.4, 含1% BSA, 和0.025% 叠氮化钠
应用摘要 :
FC, 免疫细胞化学, 免疫组化, 免疫印迹
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。